Principal Scientist, RNA Synthesis Process Sciences Cambridge - MA - US R1603715 Posted ago

Position: Principal Scientist, RNA Synthesis Process Sciences Cambridge - MA - US R1603715 Posted 16 hours ago
## Principal Scientist, RNA Synthesis Process Sciences Cambridge - MA - USFind out how well you match with this job
** Working with Us
** Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:
** Position Summary
** The Principal Scientist, RNA Synthesis Process Sciences role plays a central part in collaborating with research and manufacturing to define early process conditions and scale down process development. By combining deep scientific expertise with enabling technologies and strong cross-functional partnerships, RNA Process Development delivers transformative innovation across the pipeline.
The Principal Scientist is a scientific leader responsible for driving RNA drug substance synthesis and circularization strategies, influencing cross-functional decisions, and delivering high-impact outcomes across increasingly diverse portfolio.
The Principal Scientist provides scientific leadership for drug substance programs spanning preclinical to early stage development across circular and linear mRNA modalities. This role encompasses hands-on and technical leadership contributions by driving sound experimental execution and establishing linkages from a research concept to manufacturing implementation. The candidate should be driven by developing and characterizing RNA synthesis processes for improving the yield, quality and robustness.

** Key Responsibilities
** Scientific Leadership
* Lead RNA synthesis process research for drug substance programs across a portfolio that may include circular RNA and mRNA, spanning preclinical to early-stage development.
* Provide strategic oversight of reaction design, process development, and manufacturability, while contributing hands-on scientific input where needed to resolve critical technical challenges.
* Apply high throughput. data drive approaches to assess and mitigate risks, defining mitigation strategies and making critical scientific recommendations at key program milestones
* Represent drug substance development strategies in cross-functional CMC teams, ensuring alignment across research, analytical development, engineering, regulatory affairs, and supply chain

People Leadership & Talent Development
* Set clear priorities and objectives for Synthesis Process Sciences in alignment with portfolio goals and RNA PD’s broader organizational strategy
* Mentor and develop scientists across RNA SPS, contributing to a culture of scientific excellence and continuous learning
* Foster an inclusive, high-performance team environment built on psychological safety, accountability, and collaboration

Innovation & Organizational Contribution
* Propose and lead departmental initiatives that improve scientific workflows, sustainability practices, and operational efficiency
* Build and maintain collaborative relationships with external academic institutions and industry partners to accelerate scientific advancement
* Represent capabilities at internal reviews, scientific conferences, and through peer-reviewed publications

Cross-Functional Collaboration
* Serve as a key scientific voice in cross-functional CMC teams and broader enterprise forums
* Partner with functional areas - including research, analytical development, engineering, and drug product development
* Collaborate with organization leadership to drive strategic alignment across the portfolio
** Qualifications & Experience
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