Senior Research Associate; Oligo Chemistry & Biochemistry

Job Title

Research Associate or Associate Scientist in Oligo Chemistry and Biochemistry Research

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington's disease, as well as several preclinical programs utilizing our versatile RNA medicines platform.

Driven by the calling to "Reimagine Possible", we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Wave Life Sciences is seeking a highly motivated Research Associate or Associate Scientist in Oligo Chemistry and Biochemistry Research to join its team in Cambridge, Massachusetts. This is an ideal opportunity for an individual who is interested in learning cutting edge technologies and who thrives in a team-oriented, fast-paced, cross-disciplinary biotech environment. The candidate will take an active role in LC/MS based bioanalytical chemistry, oligonucleotide stability assay, and oligonucleotide metabolite identification for discovery and preclinical activities.

• B.S. or M.S. in Chemistry, Analytical or Bioanalytical chemistry with 1-5 years of laboratory experience.
• Experience or understanding of the extraction technique of oligonucleotide (or small molecules, biopolymers) from biological matrices.
• Experience or understanding of LC/MS analysis of oligonucleotide is highly preferred.
• Experience of laboratory software such as Chem Draw and Graph Pad is preferred.
• Demonstrable organizational and time management skills.
• Ability to be highly productive and innovative in a fast-paced work environment.

• Play a key role in LC/MS based bioanalytical chemistry with synthetic oligonucleotides for multiple projects/targets.
• Perform proper oligonucleotide extraction protocols (LLE, SPE, immunoprecipitation etc) for the sample preparation.
• In vitro stability assays of synthetic oligonucleotides in biological matrices.
• Characterization and identification of oligonucleotide metabolites from in vivo experiments by analytical techniques, such as LC/MS.
• Operate and maintain lab equipment such as LC/MS, UV spectrophotometer, Nanodrop, centrifuge, etc.
• Maintain detailed written and electronic records of experimental protocols and data in accordance with company policy.
• Presentation of results in written and oral format within a multidisciplinary team.
• Establish and maintain excellent working relationships within the team and collaborative partners throughout the company.
• This position will be in person at our Cambridge MA location, five days a week.

The annual base salary range for this position is $72,000 - $98,000.

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences' employees to perform their job duties may result in discipline up to and including discharge.

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee.

Only approved recruitment firms will be allowed to provide services to Wave Life Sciences, USA.

• Job Identification 478
• Posting Date 05/20/2026, 07:01 PM
• Job Schedule Full time
• Locations Wave…