Serif Biomedicines | Cambridge, MA Senior Scientist, LNP Process and Development

Senior Scientist, LNP Process and Development

Cambridge, MA USA

Serif Biomedicines is a privately held, early‑stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first‑in‑category life sciences companies.

We are seeking a highly motivated Scientist to support the development and scale‑up of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role will focus on process optimization and scale‑up of targeted LNPs encapsulating modified DNA and cofactor mRNA, while also contributing to research efforts aimed at improving LNP design and performance. This is an ideal opportunity for a scientist with a strong background in process development who is interested in expanding into formulation development and early‑stage R&D, including formulation screening and optimization of next‑generation LNP systems.

The successful candidate will work collaboratively within cross‑functional teams to advance LNP platform capabilities and support the development of scalable and robust nucleic acid delivery systems.

• Support process development and optimization activities for LNP formulation and scale‑up, including mixing parameters, encapsulation efficiency, and reproducibility.
• Design and execute experiments to improve the performance and manufacturability of LNPs encapsulating modified DNA and mRNA.
• Collaborate with internal and external teams to support characterization and evaluation of LNP formulations.
• Assist with technology transfer and scale‑up activities, including coordination with external partners or internal manufacturing teams.
• Analyze and interpret experimental data, maintain accurate documentation, and communicate findings to project teams.
• Stay current with advancements in LNP technologies and nucleic acid delivery approaches.

• PhD. in Chemical Engineering, Pharmaceutical Sciences, Bioengineering, or a related field, with 3+ years of relevant industry experience; M.S. with 8+ years of experience; or Bachelor with 10+ years of experience.
• Strong background in process development, scale‑up, or manufacturing of nanoparticle or LNP‑based systems.
• Experience working with nucleic acid formulations (e.g., mRNA, DNA) is highly preferred.
• Familiarity with T mixing, or similar, formulation scale‑up, and characterization techniques (e.g., DLS, encapsulation assays).
• Demonstrated ability to design experiments, analyze data, and solve complex technical problems.
• Strong communication and collaboration skills.

• Opportunity to work at the forefront of LNP formulation innovation
• Collaborative, science‑driven culture with high impact research
• Competitive compensation and benefits package

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

The salary range for this role is $100,000 - $143,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicines's good faith estimate as of the date of publication and may be modified in the future.