Senior Associate Scientist - Discovery Research, Regeneron Cell Medicines

We are seeking a highly motivated and innovative Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. You will be performing immunological function assays for analyzing genetically engineered human primary T cells (CAR‑T or TCR T cells) from both early discovery programs as well as late‑stage development programs’ non‑clinical studies that support regulatory submissions. The role is hands‑on in a fast‑paced laboratory environment.

• Contribute to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications.
• Characterize genetically modified primary human T cells via immunophenotyping using multi‑color flow cytometry and molecular assays (PCR, library preps for NGS, RNA‑Seq).
• Develop and perform immunological functional assays to assess immune cell activation, anti‑tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR‑based T‑cell therapeutics.
• Design experiments independently and contribute to project direction.
• Maintain an electronic lab notebook and document experiment results.
• Review and present research data to the functional team.

• At least a BS/MS in immunology, cell biology, or a related field and 3+ years of relevant experience in a biotech/pharmaceutical industry.
• Strong understanding of immunology and cancer biology.
• Extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including primary human T lymphocyte culture.
• Experience in in‑vitro immunological studies and development of functional T cell assays using multi‑color flow cytometry, ELISA, and cytotoxicity assays.
• Experience with gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation is a plus.
• Familiarity with standard molecular biology techniques, including but not limited to PCR, qPCR, Western blotting, and library preps for NGS, RNA‑Seq.
• Strong verbal and written communication skills, self‑starter, highly organized, excellent attention to detail, and the ability to manage multiple tasks efficiently.

Salary: $80,300.00 – $ annually.

• Competitive and comprehensive total rewards package including annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match.
• Health and wellness programs, fitness centers, insurance benefits (medical, dental, vision, life, and disability), paid time off, and family support benefits.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience.

In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.