Senior Associate Scientist - Discovery Research, Regeneron Cell Medicines

Job Summary

We are seeking a highly motivated and innovative Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. You will be performing immunological functional assays for analyzing genetically engineered human primary T cells (CAR‑T or TCR T cells) from both early discovery programs as well as late‑stage development programs’ nonclinical studies that support regulatory submissions. We hope you are excited to be in a hands‑on laboratory role in a fast‑paced environment.

• Contributing to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications
• Characterizing genetically modified primary human T cells via immunophenotyping using multi‑color flow cytometry and molecular assays (PCR, library preps for NGS, RNA‑Seq)
• Developing and performing immunological functional assays to assess immune cell activation, anti‑tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR‑based T‑cell therapeutics
• Designing experiments independently and contributing to the project direction
• Maintaining an electronic lab notebook and documenting experiment results
• Reviewing and presenting research data to the functional team

• Have a can‑do attitude, are curious, and excel in creative problem solving
• Can multi‑task and manage time well
• Can quickly adapt to new research areas and implement new techniques independently
• Are scientifically rigorous, highly organized, and a self‑starter with excellent attention to detail
• Have strong verbal and written communication skills
• Are self‑motivated and enthusiastic about working in an interdisciplinary, collaborative research environment

In order to be considered for this role, you must have at least a BS/MS in immunology, cell biology or related field and 3+ years of relevant experience. Must have experience working in a biotech/pharmaceutical industry. We need someone with a strong understanding of immunology and cancer biology. Must have extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including cell culture of primary human T lymphocytes.

Experience working on in‑vitro immunological studies and development of functional T cell assays using techniques such as multi‑color flow cytometry, ELISA and cytotoxicity assays is required. Gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation a plus. Experience with standard molecular biology techniques, including but not limited to PCR, qPCR, Westerns, and library preps for NGS, RNA‑Seq also advantageous.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

$80,300.00 – $

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.