Senior Associate Scientist - Discovery Research, Cell Medicines

Senior Associate Scientist

We are seeking a highly motivated and innovative Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. You will be performing immunological functional assays for analyzing genetically engineered human primary T cells (CAR-T or TCR T cells) from both early discovery programs as well as late-stage development programs' nonclinical studies that support regulatory submissions. We hope you are excited to be in a hands-on laboratory role in a fast-paced environment.

As a Senior Associate Scientist, a typical day might include:

• Contributing to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications
• Characterizing genetically modified primary human T cells via immunophenotyping using multi-color flow cytometry and molecular assays (PCR, library preps for NGS, RNA-Seq)
• Developing and performing immunological functional assays to assess immune cell activation, anti-tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR-based T-cell therapeutics
• Designing experiments independently and contributing to the project direction
• Maintaining an electronic lab notebook and documenting experiment results
• Reviewing and presenting research data to the functional team

This role might be for you if you:

• Have a can-do attitude, are curious, and excel in creative problem solving
• Can multi-task and manage time well
• Can quickly adapt to new research areas and implement new techniques independently
• Are scientifically rigorous, highly organized, and a self-starter with excellent attention to detail
• Have strong verbal and written communication skills
• Are self-motivated and enthusiastic about working in an interdisciplinary, collaborative research environment

In order to be considered for this role, you must have at least a BS/MS in immunology, cell biology or related field and 3+ years of relevant experience. Must have experience working in a biotech/pharmaceutical industry. We need someone with a strong understanding of immunology and cancer biology. Must have extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including cell culture of primary human T lymphocytes.

Experience working on in-vitro immunological studies and development of functional T cell assays using techniques such as multi-color flow cytometry, ELISA and cytotoxicity assays is required. Gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation a plus. Experience with standard molecular biology techniques, including but not limited to PCR, qPCR, Westerns, and library preps for NGS, RNA-Seq also advantageous.