Senior Scientist II​/Principal Scientist, Molecular Cloning Technologies

Senior Scientist II/Principal Scientist, Molecular Cloning Technologies

Cambridge, MA USA

Founded through Flagship Pioneering's venture creation engine, Terrana Biosciences is a cutting-edge agricultural biotechnology company developing innovative RNA-based products to address global agricultural challenges. We are committed to advancing sustainable farming solutions through precision technologies that ensure environmental safety and regulatory compliance.

Terrana Biosciences is building a new generation of RNA-based technologies to transform agriculture. We are seeking an innovative and strategic Principal Scientist, Molecular Cloning Technologies to lead the vision, development, and scaling of cloning and construct generation capabilities across the company.

As a scientific leader, you will define and drive cloning strategies that accelerate discovery, platform development, and product advancement. You will serve as the technical authority for molecular cloning technologies, develop novel high-throughput workflows, and identify emerging approaches that strengthen Terrana's RNA technology platform. This role requires a highly creative scientist who thrives at the intersection of technology innovation, scientific leadership, and operational excellence.

• Define and execute the long-term cloning strategy supporting Terrana's research and platform development efforts.
• Own the cloning function and construct generation operations at Terrana, ensuring reliable, scalable, and cost-effective delivery of high-quality constructs supporting company pipeline activities.
• Conceive, develop, and implement novel cloning technologies, workflows, and automation solutions to enable rapid construct generation and testing.
• Drive continuous improvements in construct generation throughput, turnaround time, automation, quality, and unit economics while expanding organizational capacity.
• Lead innovation in high-throughput DNA assembly, plasmid engineering, vector development, and viral engineering technologies.
• Evaluate emerging technologies and establish new capabilities that improve speed, scale, quality, and efficiency.
• Partner closely with Molecular Biology, Delivery, Discovery, Sequencing, and Bioinformatics teams to enable key research objectives and accelerate innovation.
• Mentor scientists and contribute to the development of technical talent and scientific culture across the organization.
• Drive external collaborations and represent Terrana's cloning capabilities with scientific partners and collaborators.
• Communicate scientific strategy, findings, and recommendations to senior leadership.

• Ph.D. in Molecular Biology, Synthetic Biology, Biotechnology, Biochemistry, Plant Biology, or a related field.
• Senior Scientist II:
  Ph.D. and 8-11 years of relevant industry and/or postdoctoral experience with a demonstrated record of scientific leadership and innovation.
• Principal Scientist:
  Ph.D. and 12+ years of relevant industry and/or postdoctoral experience with a demonstrated record of scientific leadership and innovation.
• Demonstrated ability to balance scientific leadership with hands-on laboratory execution in a fast-paced, resource-constrained environment.
• Deep expertise in molecular cloning, DNA assembly technologies, vector engineering, and construct design.
• Proven track record of developing and implementing novel technologies or platform capabilities.
• Experience leading complex, cross-functional scientific initiatives from concept to execution.
• Experience developing, implementing, and scaling high-throughput cloning workflows, laboratory automation solutions, and production operations.
• Strong communication, influence, and problem-solving skills.
• Demonstrated creativity, scientific rigor, and an entrepreneurial mindset.

Preferred Qualifications

• Expertise in viral vector biology, host-virus interactions, plant virology, or RNA virus engineering.
• Experience in agricultural biotechnology, plant biology, microbial engineering, or RNA-based technologies.
• Familiarity with automated liquid handling platforms and laboratory information management systems (LIMS).
• Working knowledge of sequencing-based construct verification and associated data analysis workflows.

Location:

Cambridge, MA

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business…