Principal Scientist II - Pharmacology

Job Description Summary

NI  Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR‑T, and radioligand therapy. We are seeking an in‑vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will lead design and execution of in‑vivo anti‑tumor efficacy and PK/PD studies, develop novel in‑vivo assays, and deliver translationally relevant data to inform clinical development.

Location:

Cambridge, MA. This position is onsite only; remote work is not possible. Please only apply if you can work in this area.

• Design pre‑clinical in‑vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof‑of‑concept of new modalities
• Develop in‑vivo CDX, PDX, and syngeneic models to evaluate anti‑tumor activity, PK/PD relationships, relevant biomarkers, and key translational questions
• Manage associate‑level scientists
• Collaborate with cross‑functional project teams
• Critically analyze and present results within a multidisciplinary team environment
• Ensure careful adherence to animal protocols and proper documentation of data and methods in an electronic laboratory notebook

• PhD with 5‑8 years of research experience as a postdoctoral fellow or in the pharmaceutical/biotech industry
• Deep knowledge of antibody drug conjugates
• Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models
• Expertise in cell culture, PCR, ELISA, western blot, and flow cytometry
• Strong analytical, written and verbal communication, and organizational skills; proficiency with PowerPoint and commonly used data analysis programs such as Prism and Excel

The salary for this position is expected to range between $126,000 and $234,000 per year. Compensation includes a performance‑based cash incentive and, depending on the level of the role, eligibility for annual equity awards. US‑based eligible employees receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.

Employees are also eligible for a generous time‑off package including vacation, personal days, holidays, and other leaves.

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Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Communication Skills, Curious Mindset, Data, Data Analysis, Design Of Experiments, Detail‑Oriented, Drug Development, Drug Discovery, Ethics, Gene Therapy, Immunology, Inventory Management, Laboratory, Lifesciences, Machine Learning (ML), Management, Medical Research, Molecular Biology {+ 10 more}

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

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