Senior Manager, Viral Vectors

Senior Manager, Viral Vectors – Cambridge, MA

We are looking for a Senior Manager to lead a discovery research Viral Vector Core team in Cambridge, MA. This individual will be a key scientific leader responsible for overseeing research‑scale viral vector production, purification, and analytical testing in a discovery research setting, acting as a bridge with colleagues in process development. The ideal candidate will have extensive experience with lentiviral vectors and a proven track record of managing a high‑performing scientific team.

This is a unique opportunity to play a critical role in advancing our cutting‑edge therapeutic pipeline.

• Provide scientific direction and operational oversight for the Viral Vector Core. Lead a team of scientists and associates in the design, execution, and troubleshooting of all vector production and characterization activities.
• Direct the upstream (cell culture, bioreactor process) and downstream (purification, concentration) development activities for discovery research viral vector manufacturing. Drive the optimization and scaling of processes from 96‑well plates to 1L bioreactor scale.
• Oversee the development, validation, and implementation of a comprehensive suite of analytical assays to ensure the quality, safety, and potency of all viral vectors. This includes assays for biophysical characterization, particle quantitation (ddPCR, qPCR, ELISA), and functional assessment (titer, potency).
• Collaborate with colleagues in process development to inform and align on vector production and testing activities.
• Act as the primary point of contact for the Viral Vector Core, collaborating closely with discovery research and preclinical teams to ensure the timely delivery of high‑quality vectors for all studies as well as other vector core groups for aligned methods.
• Stay abreast of the latest advancements in the field of viral vector engineering, production, and analytics. Identify, evaluate, and implement new technologies to enhance the capabilities of the core.
• Foster a culture of scientific excellence, collaboration, and continuous improvement. Mentor and develop team members, providing guidance and support for their scientific and professional growth.

• Ph.D. in Virology, Molecular Biology, Bioengineering, or a related discipline with a minimum of 6 years of experience in the biopharmaceutical industry.
• Extensive hands‑on experience and a deep theoretical understanding of viral vector biology, particularly lentiviral systems.
• Proven track record of leading and managing a scientific team in a fast‑paced, results‑oriented environment.
• Demonstrated expertise in the development and optimization of upstream and downstream processes for viral vector production in a research setting.
• In‑depth knowledge and practical experience with a wide range of modern analytical techniques for vector characterization.
• Exceptional problem‑solving skills and the ability to think critically and creatively.
• Outstanding communication and interpersonal skills, with the ability to effectively communicate complex scientific concepts to diverse audiences.
• Demonstrated operational expertise, including hands‑on experience implementing Laboratory Information Management Systems (LIMS) for robust data and material tracking. Proven ability to create certificates of testing and reports, with a successful track record of aligning analytical methods across teams.

Base pay range: $137,000 – $235,750.

Pay transparency:
Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

• Vacation – 120 hours per calendar year
• Sick time – 40 hours per calendar year (48 hours for Colorado residents, 56 hours for Washington residents)
• Holiday pay, including floating holidays – 13 days per calendar year
• Work, personal and family time – up to 40 hours per calendar year
• Parental leave – 480 hours within one year of birth/adoption/foster care of a child
• Bereavement leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
• Caregiver…