Research Scientist I​/II: Pharmacology

Overview

Over 40 therapies in the clinic! NI  Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR‑T, and radioligand therapy. NI  is seeking a lab‑based in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi‑disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early‑stage drug discovery pipeline.

The primary responsibility of this position will be to execute in vivo anti‑tumor efficacy and PK/PD studies aimed at evaluating novel drug candidates in CDX, PDX, and syngeneic models. Applicants are expected to spend the majority of their time in the lab. Qualified candidates will be proficient in animal handling techniques and compound administration, while possessing a variety of molecular biology and flow cytometric skills.

We are looking for highly motivated, inquisitive, and creative individuals, who thrive in a highly‑matrixed work environment, and can effectively communicate within multidisciplinary project teams.

• Hands‑on execution of pre‑clinical in‑vivo studies to explore novel hypotheses, screen candidate molecules, and establish proof‑of‑concept.
• Develop in‑vivo CDX, PDX, and syngeneic models to evaluate anti‑tumor activity, PK/PD relationships, and relevant biomarkers of novel compounds to support clinical development.
• Work independently and in collaboration with other colleagues in pharmacology to execute studies.
• Critically analyze and present results within a multidisciplinary team environment.
• Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook.

• Research ScientistI position: BS/MS in biological sciences with 2+ years of relevant research experience in the pharmaceutical/biotech industry.
• Research Scientist II position: BS/MS in biological sciences with 4+ years of relevant research experience in the pharmaceutical/biotech industry.
• Extensive experience working with CDX and PDX xenograft tumor models and/or syngeneic models.
• Experience with cell culture.
• Hands‑on mouse/rat handling skills, including dosing (IV, IP, PO), tumor implantation, caliper tumor measurements, xenogen imaging, and blood/tissue collection techniques.
• Experience with PCR, ELISA, western blot, and flow cytometry.
• Strong analytical, communication (written and verbal), and organizational skills, including proficiency with PowerPoint and commonly used data analysis programs, such as Excel and Prism.

The salary ranges for this position are as follows:
Research ScientistI: $66,800 – $124,000 per year. Research Scientist II: $81,200 – $150,800 per year. The final salary offered is determined based on relevant skills and experience and will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance‑based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US‑based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.