Scientist, Ligand Binding Assays

The Bioanalytical Sciences group at Alnylam is seeking a highly motivated Scientist, specializing in ligand binding assays to quantify oligos, proteins, peptides, and antibodies.

This individual will be responsible for supporting fit-for-purpose methods across various technologies, such as hybridization ELISA, ELISA, MSD, FACS, ELLA, and Quanterix, to support early through late-stage drug development programs to inform on target engagement, pharmacodynamics (PD), pharmacokinetics (PK), mechanism of action, and safety, to advance RNAi therapeutic development.

The ideal candidate will have a strong background in molecular biology or biochemistry, broad understanding of biology, and exceptional problem-solving and communication skills to successfully collaborate with multiple project teams in a matrixed and fast-paced environment. This is an exciting opportunity to join a vibrant team and interact with highly motivated scientists across a broad array of disciplinary expertise areas.

This position is onsite and will be primarily located in Cambridge, MA.

• Design, develop, and implement ligand binding assays (ELISA, MSD, Quanterix), in a variety of biological matrices to support the analysis of drug PK, PD & biomarker, with minimal direction. Independently and reliably conduct non-GLP sample analysis to support all Alnylam's RNAi therapeutic development from early to late stages
• Ability to complete projects in a timely and clearly documented manner.
• Aid in critically reviewing and troubleshooting internal and external ligand-binding assays
• Assist associate scientists in method optimization and troubleshooting assays
• Help implement and maintain appropriate procedures and controls to ensure consistent assay performance and reproducible data.
• Maintain laboratory notebooks, perform data analysis and QC, and communicate results to a broad and/or specialized team
• Understand project goals and ability to make decisions independently
• Apply an in-depth understanding of the technologies and intended use of the results to aid in interpretation of data
• Independently prepares presentations and effectively communicates with broader matrixed teams to demonstrate subject matter leadership
• Independently author SOPs and reports for LBA methods and support method transfers to CROs, as needed.
• Research and implement new technologies to improve assay performance or address specific questions.
• Investigate areas for automation to increase quality or efficiency.

• Ph.D. in biochemistry, chemistry, molecular/cell biology, or related field with 0+ years of relevant industry experience or exceptional non-PhD (Masters degree with 8+ years, or Bachelors degree with 10+ years of industry experience)
• Possesses in-depth knowledge, hands on experience, and technical expertise on ligand binding assays. Knowledge of Liquid Handlers/Automated ELISA (e.g., Biomek), FACS and LCMS methods is a plus.
• Knowledge of regulatory expectations for bioanalytical method validation or previous experience working in a bioanalytical GLP or non-GLP environment is preferred.
• Demonstrates a solid understanding of disease biology and the drug development process to enable design and implementation of assays that are fit for intended use.
• Track record in preparing conference presentations, publications in peer reviewed journals, or industry and regulatory white papers.
• Demonstrates strong problem solving ability and adaptability, in and out of their comfort zone
• Detail-oriented with exceptional organizational skills, and the ability to handle multiple projects, and thrive in a fast-paced, team-oriented environment
• Has strong interpersonal skills to enable collaboration with cross-functional teams.
• Possesses excellent verbal and written communication skills.

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The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k) with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave.

Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website:

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