Senior Associate Scientist, LC​/LC-MS

Working with Us

Challenging. Meaningful. Life‑changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high‑achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:  .

BMS at Kendall Square is seeking a highly skilled and motivated Senior Associate Scientist with strong expertise in analytical method development to support the advancement of novel RNA therapeutics. The successful candidate will leverage liquid chromatography and LC/MS technologies to design, develop, and execute analytical methods that enable comprehensive characterization of lipids, antibodies, and RNA‑based modalities across discovery and development stages.

This role will play a critical part in generating high‑quality analytical data to support product understanding, process development, and CMC strategies.

• Independently design, develop, and optimize analytical methods to characterize RNA‑based therapeutics, lipid nanoparticles, and related components using advanced LC and LC/MS platforms.
• Lead phase‑appropriate method lifecycle activities, including method development, qualification, validation, and transfer to internal and external laboratories (e.g., CROs/CDMOs), with authorship of SOPs, protocols, and technical reports.
• Collaborate cross‑functionally with process development, formulation, research, and manufacturing teams to support analytical development, troubleshoot issues, and enable program milestones and timelines.
• Troubleshoot complex analytical challenges, interpret data, and provide scientifically sound recommendations to resolve issues and improve assay performance and robustness.
• Perform and oversee routine and non‑routine analytical testing, including data review, verification, and interpretation to ensure data quality, integrity, and compliance with internal standards.
• Operate, maintain, and troubleshoot LC and MS instrumentation.
• Analyze and communicate complex analytical data, generating clear, concise reports and presentations to inform technical teams and leadership decisions.

• B.S./M.S. in Analytical Chemistry, Biochemistry, or a related discipline with 2+ years of relevant CMC‑related experience;
  PhD. candidates with the appropriate experience will be considered.
• Experience with LC‑MS method development, impurity characterization, and structural elucidation using high‑resolution MS platforms.
• Experience with LNP drug products, antibodies, and RNA/oligonucleotide analysis preferred.
• Ability to manage multiple projects and priorities in a fast‑paced environment.
• Strong technical writing skills for reports, protocols, and regulatory documentation.
• Familiarity with regulatory expectations (e.g., ICH, FDA) for analytical data and submissions.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Cambridge - MA - US: $96,010 - $116,339

The starting compensation range(s) for this role are listed above for a full‑time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job‑related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.

Eligibility…