Associate Scientist​/Scientist , LNP Formulations

Company Description

Mirai Bio is a Flagship-backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. Mirai’s platform integrates nanoparticle development with world‑class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies.

We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Mirai Bio is seeking a scientist to advance our lipid nanoparticle (LNP) delivery platform for nucleic acid therapeutics. We are seeking a highly talented and motivated individual to develop and optimize lipid nanoparticle (LNP) formulations. The successful candidate will contribute to both platform innovation and preclinical pipeline programs, working at the interface of formulation science, chemistry, analytical characterization, and process development.

• Design, formulate, and characterize lipid nanoparticle (LNP) systems for nucleic acid delivery across early research and preclinical development stages
• Develop and optimize formulation processes, including microfluidic mixing and scale‑up approaches (e.g., TFF, ultrafiltration)
• Screen and evaluate novel ionizable lipids and LNP compositions; analyze structure‑function relationships to improve delivery performance
• Troubleshoot formulation and process challenges to enhance robustness, reproducibility, and scalability
• Generate high‑quality, reproducible data and maintain thorough documentation in electronic lab notebooks
• Prepare LNP formulations to support internal research and partner programs
• Collaborate cross‑functionally with analytical, translational, and tech development teams to advance platform goals
• Present data and insights clearly to internal teams and contribute to scientific discussions and decision‑making

• Ph.D. and 0‑1 years or 4+ years (M.Sc.) or 6+ years (B.Sc.) of relevant industry experience in LNP formulation optimizations and drug delivery with strong background in nucleic acid therapeutics and education in life sciences or engineering (Pharmaceutical Sciences, Biomedical Engineering, Biochemistry, etc.)
  • Level (Associate Scientist or Scientist I) will be determined based on experience, technical expertise, and demonstrated impact.
• Hands‑on experience in nanoparticle or LNP formulation and characterization
• Strong understanding of drug delivery systems, particularly for nucleic acid therapeutics
• Experience with nanoparticle characterization techniques (e.g., DLS, zeta potential, fluorescence‑based assays such as Ribogreen, chromatography)
• Demonstrated ability to design, execute, and troubleshoot experiments independently
• Strong data analysis, documentation, and communication skills

• Familiarity with formulation process technologies (e.g., microfluidic mixers, pumping systems, TFF)
• Experience with high‑throughput formulation screening approaches
• Knowledge of lipid chemistry, ionizable lipid design, or bioconjugation techniques
• Experience supporting in vivo studies or translating formulations from research to preclinical scale

Cambridge, MA

The salary range for this role is $96,000 - $134,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Mirai Bio currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Mirai Bio’s good faith estimate as of the date of publication and may be modified in the future.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.