Senior Principal Scientist, Immune Cell Depletion Discovery Group, Immunology Discovery Research

Job Description

The Immunology Discovery Therapeutic Area is seeking an accomplished and experienced Scientist to lead the Immune Cell Depletion Group within the Immune Reset Therapeutics Discovery team based in Cambridge, MA. In this role you will lead a multidisciplinary team of highly talented scientists with experimental, technical and scientific expertise in cellular depletion approaches. The candidate should have a demonstrable track record in this scientific discipline, alongside a strong knowledge of preclinical drug discovery spanning target discovery/validation through to GLP toxicology phases.

The ability to effectively collaborate and deliver results across multi-disciplinary line functions both internally and with external leading experts is required. Proven expertise leading preclinical drug discovery programs leveraging cellular depletion approaches in autoimmune disease is an advantage. Applicants should have a strong publication record and have proven experience in leading and developing bench-based scientists.

• Lead the Immune Cell Depletion Group within Immunology Discovery. Responsible for refining strategy and biology focus within this area to support and advance the portfolio.
• Provide biology expertise to internal teams that helps pave the way for next-generation therapies that leverage cell depletion approaches to develop next generation therapies for rheumatological, dermatological, gastroenterological and respiratory diseases.
• Key member of the Immune Reset Therapeutics Discovery Leadership Team, to support advancement of Immune Tolerance biology into the drug discovery pipeline.
• Proven experience in managing, growing and developing highly talented scientists.
• Drive performance by Leading from the Bench, including the ability to design and execute key experiments to inform decision-points (GO / NO-GO) at critical stages of projects.
• Proven track record of leading and influencing early to late-stage discovery programs.
• Deep immunology expertise, with emphasis on understanding how cell depletion approaches can potentially raise the treatment ceiling for patients with autoimmune disease.
• Help develop and execute a strategy in alignment with functional goals and key scientific objectives in discovery immunology research.
• Highly collaborative, team-oriented, and considerate of the needs of others.
• Strong interpersonal skills and ability to collaborate with diverse groups within the organization and external partners.
• Highly organized and self-directed, capable of leading multiple complex research programs in parallel.
• Excellent written and verbal communication skills, as well as critical evaluation and data-driven decision making.
• Provide expert advice and share knowledge with direct reports, peers, and senior leadership.
• Establish and manage external collaborations with leading research labs around the world, including attendance and presentation at conferences and submission of publications.

• 18+ years of related work experience in academia, biotech or pharma, or 16+ years, or 10+ years if holding a PhD.
• Extensive experience in Immunology drug discovery within a high-caliber research environment and at least 6+ years of related experience in biotech or pharma.
• Ability to create an inclusive environment where diverse ideas, viewpoints and backgrounds are valued; willingness and ability to lead inclusively and demonstrate a commitment to listening and considering all points of view.
• Ability to work, influence, lead and deliver results in cross-functional teams.
• Excellent written, presentation and interpersonal communication skills; ability to be effective in a highly collaborative environment.

• Builds strong relationships with peers and partners across the organization to enable high performance.
• Learns fast, grasps the "essence" and can change course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our long-term incentive programs.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled. US & Puerto Rico only - to learn more, visit

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