Principal Scientist, Biomarker Assay Development Bench Scientist
Job in
Cambridge, Middlesex County, Massachusetts, 02140, USA
Listed on 2026-07-06
Listing for:
Novartis Farmacéutica
Full Time
position Listed on 2026-07-06
Job specializations:
-
Research/Development
Research Scientist, Biotech Research, Clinical Research, Immunology Research
Job Description & How to Apply Below
USA Available in:
English### Summary Internal
Position Title:
Principal Scientist I/II
Location:
Cambridge, MA, #LI-Onsite This role is based in Cambridge, MA. Novartis is unable to offer relocation support for this role: please only apply if this location is accessible for you.
Novartis Biomedical Research is seeking a highly skilled and motivated Principal Scientist (Level
4) to conduct bench research in a laboratory focused on preclinical and clinical biomarker assay development within Disease Area X (DAx). This position is integral to designing, developing, and qualifying biomarker assays that support drug discovery and development programs across DAx’s diverse portfolio, including renal, liver, fibrosis, and exploratory indications. The successful candidate will work collaboratively within a matrixed team and contribute technical expertise to translational strategies that enable patient stratification and clinical impact.###
About the Role
*
* Key responsibilities:
*** Design, develop, and qualify preclinical and clinical biomarker assays (cellular, soluble, proteomic, genetic, and genomic) to support target engagement, pharmacodynamics, and patient stratification for DAx programs.
* The ideal candidate will bring deep technical and strategic expertise in designing, developing, optimizing, and clinically implementing ligand binding assays (e.g. ELISA, MSD, immunoassays). Ensuring analytical rigor, robustness, and “fit-for purpose” performance expectations and technical assessment standards.
* Execute laboratory-based research, including hands-on assay development, optimization, and troubleshooting.
* Analyze and interpret experimental data, ensuring scientific rigor and reproducibility.
* Collaborate with Translational Medicine, Biomarker Development, and DAx project teams to align assay strategies with DAx therapeutic area priorities.
* Support the implementation of biomarker assays in preclinical and clinical studies, including documentation and reporting of results.
* Maintain exemplary laboratory practices, including accurate record keeping and adherence to safety and regulatory guidelines.
* Present research findings in lab meetings and contribute to scientific publications and internal reports.
** Essential Requirements**:
* PhD or MD, Postdoctoral Fellowship preferred, with 4+ years’ experience in scientific and technical discipline of relevant field, or BS/MS with 8+ years’ experience in scientific and technical discipline of relevant field.
* Hands-on experience with designing and executing LBA assays
* Demonstrated experience in biomarker assay development, proteomics, genetics, genomics, or related fields within pharma or biotech.
* Demonstrated expertise in assay development, qualification, and implementation for preclinical and/or clinical studies across various animal and human matrices.
* Proven skill in independently developing and executing biochemical and cellular assays for drug discovery.
* Innovative and critical thinking, with a track record of scientific impact and continuous improvement.
* Excellent oral and written communication skills.
* Commitment to scientific rigor, curiosity, and accountability in laboratory research.
** Desirable Requirements:
*** Experience with multiomics profiling and patient stratification approaches, especially as applied to renal, liver, fibrosis, or exploratory disease areas.
* Familiarity with animal models and ex vivo assays is a plus.
* Hands-on experience with RNA assays and/or LC-MS based biomarker or assay quantification an added plus.
* Knowledge of statistics and computational data analysis is desirable.
* Experience working with CROs or external vendors to support assay development, biomarker studies or analytical deliverables.
The salary for this position is expected to range between $108,500 and $201,500 per year for Principal Scientist I, and $126,000 and $234,000 per year for Principal Scientist II. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed…
To View & Apply for jobs on this site that accept applications from your location or country, tap the button below to make a Search.
(If this job is in fact in your jurisdiction, then you may be using a Proxy or VPN to access this site, and to progress further, you should change your connectivity to another mobile device or PC).
(If this job is in fact in your jurisdiction, then you may be using a Proxy or VPN to access this site, and to progress further, you should change your connectivity to another mobile device or PC).
Search for further Jobs Here:
×