Senior Scientist, Medicinal Chemistry, Integrated Drug Discovery

Job title:

Senior Scientist, Medicinal Chemistry, Integrated Drug Discovery

Location:

Cambridge, MA

An accomplished synthetic organic and medicinal chemist, with a track record of impactful project contributions in design and synthesis. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI‑powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

• Design and synthesize small molecule targets to drive programs to clinical candidate nomination.
• Use reaction and reagent databases to select effective methods/routes to maximize productivity and provide solutions to complex multi‑step synthetic problems.
• Prepare and characterize high‑purity target compounds and intermediates to meet aggressive project timelines.
• Proficiency with the use of analytical techniques for structural characterization and ability to interpret complex NMR spectra.
• Register compounds in corporate database and maintain notebooks according to SOP.
• Champion new chemistry techniques, reagents and methodology in discovery chemistry and participate in group/lab responsibilities.
• Understand project SAR, adapt and prioritize work proactively based on emerging data.
• Interpret biological data (DMPK, pharmacology, safety) to contribute to project advancement.
• Work independently, proactively and collaboratively with other team members to design compounds to address key issues.
• Dedication to lifelong learning.
• Articulate the scientific rationale of the project to other scientists.
• Provide formal and informal mentoring to junior staff members.
• Determine the relevance of patent search results and assess the patentability of new targets.
• Assist with filing patent applications by reviewing claims and providing experimental data.
• Actively participate in medicinal chemistry discussions, communicating science clearly and precisely; proactively raise issues that positively influence program direction.
• Communicate and interact with other staff members in a professional and courteous manner.
• Operate in the lab safely and efficiently according to HSE guidelines and adhere to all mandatory company compliance requirements.
• Adapt to changes and challenges in a productive and professional manner.
• Represent the department at scientific meetings to stay up to date with current literature and industry direction.

• Bachelor’s Degree in chemistry or related field with minimum 7 years of relevant research experience in an academic or biopharmaceutical setting; OR Master’s Degree with minimum 4 years of relevant research experience; OR PhD with minimum 2 years of relevant research experience.
• Deep knowledge of organic chemistry and a growing understanding of medicinal chemistry principles.
• Experience with Induced Proximity Modalities preferred.

• Thoughtful, well‑crafted rewards package that recognizes your contribution and amplifies your impact.
• Wide range of health and wellbeing benefits including high‑quality healthcare, prevention and wellness programs, and at least 14 weeks of gender‑neutral parental leave.
• Pioneering biopharma company that engages patients early in drug development and uses their insights to design studies reflecting real‑world needs.
• Opportunities to grow your talent and drive your career, including promotions or lateral moves, at home or internationally.
• Salary range: $ – $, commensurate with experience.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and affirmative action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital status, civil partnership, sex, gender, gender identity or expression, sexual orientation, disability, veteran or military status, or any other characteristic protected by law.