Senior Associate Scientist - Discovery Research, Regeneron Cell Medicines

We are seeking a highly motivated and innovative Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. You will be performing immunological functional assays for analyzing genetically engineered human primary T cells (CAR‑T or TCR T cells) from both early discovery programs as well as late‑stage development programs' nonclinical studies that support regulatory submissions. We hope you are excited to be in a hands‑on laboratory role in a fast‑paced environment.

• Contributing to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications
• Characterizing genetically modified primary human T cells via immunophenotyping using multi‑color flow cytometry and molecular assays (PCR, library preps for NGS, RNA‑Seq)
• Developing and performing immunological functional assays to assess immune cell activation, anti‑tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR‑based T‑cell therapeutics
• Designing experiments independently and contributing to the project direction
• Maintaining an electronic lab notebook and documenting experiment results
• Reviewing and presenting research data to the functional team

• Can‑do attitude, curiosity and excel in creative problem solving
• Can multi‑task and manage time well
• Can quickly adapt to new research areas and implement new techniques independently
• Scientifically rigorous, highly organized, self‑starter with excellent attention to detail
• Strong verbal and written communication skills
• Self‑motivated and enthusiastic about working in an interdisciplinary, collaborative research environment

Required qualifications

• BS/MS in immunology, cell biology or related field and at least 3+ years of relevant experience in a biotech/pharmaceutical industry
• Strong understanding of immunology and cancer biology
• Extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including culture of primary human T lymphocytes
• Experience in in‑vitro immunological studies and development of functional T cell assays using multi‑color flow cytometry, ELISA and cytotoxicity assays
• Experience with gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing and mRNA electroporation (plus)
• Experience with standard molecular biology techniques, including PCR, qPCR, Westerns, and library preps for NGS, RNA‑Seq

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

$80,300.00 – $