Scientist II, Antisense​/siRNA and Peptide Purification

About This Role

At Biogen, we are advancing science to transform patients’ lives. We are seeking a highly motivated Scientist II to join our Technical Development team in Cambridge, MA, focused on oligonucleotide (Antisense/siRNA) and Peptide Purification. This is an exciting opportunity to design and develop robust, scalable purification processes that directly impact clinical and commercial therapeutics. You will play a key role in advancing next‑generation modalities by bridging early development with manufacturing, working in a highly collaborative, cross‑functional environment.

Your work will contribute to building state‑of‑the‑art platform processes that improve product quality, scalability, and efficiently enabling delivery of innovative therapies to patients.

• Design, develop, and scale purification processes across development stages (early development through commercial)
• Apply data‑driven approaches (e.g., DoE) to characterize processes and define robust control strategies
• Lead or support technology transfer of processes into GMP manufacturing
• Troubleshoot process challenges and drive continuous improvement in process performance
• Collaborate with Manufacturing, Analytical, Quality, Non‑Clinical, and Regulatory teams to enable program advancement
• Author technical reports and contribute to CMC sections of regulatory filings and respond to agency questions

You are a hands‑on purification scientist who thrives in a dynamic, team‑oriented environment. You possess strong analytical skills, and a keen ability to apply statistical analysis to complex data. You have a natural curiosity and a passion for process development. Your technical writing and communication skills are excellent, enabling you to effectively present technical data and contribute to regulatory documentation.

• Ph.D. degree in chemical engineering, chemistry, or a related science with 0-3 years of experience
• Master’s degree in chemical engineering, chemistry, or a related science with 4+ years of experience in pharmaceutical or biotech settings
• Bachelor’s degree in chemical engineering, chemistry, or a related science with 6+ years of relevant experience in pharmaceutical or biotech settings
• Experience in purification process development, preferably in an industrial environment
• Strong analytical skills and statistical analysis expertise
• Proficiency in technical writing and presenting technical data

• Experience in developing processes for oligonucleotides, peptides, and/or proteins
• Familiarity with GMP manufacturing processes
• Collaborative mindset with experience working in cross‑functional teams

Management

The base compensation range for this role is: $ - $. Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short‑term and long‑term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

• Medical
• Dental
• Vision
• Life insurances
• Fitness & Wellness programs including a fitness reimbursement
• Short‑and Long‑Term Disability insurance
• A minimum of 15 days of paid vacation and an additional end‑of‑year shutdown time off (Dec
  26-Dec
  31)
• Up to 12 company paid holidays + 3 paid days off for Personal Significance
• 80 hours of sick time per calendar year
• Paid Maternity and Parental Leave benefit
• 401(k) program participation with company matched contributions
• Employee stock purchase plan
• Tuition reimbursement of up to $10,000 per calendar year
• Employee Resource Groups participation

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E‑Verify Employer in the United States.