Associate Director, ADC platform in Oncology Drug Discovery

Key Responsibilities

• Lead scientific strategy for ADC payload selection, linker design, conjugation approaches, and related platform innovations
• Apply expertise across payload classes, mechanisms of action, potency, resistance biology, bystander activity, and tolerability to guide program design
• Partner with chemistry, biology, protein engineering, pharmacology, translational sciences, and CMC to advance next-generation ADCs
• Evaluate and prioritize novel payloads, linker technologies, and conjugation approaches for internal programs and external opportunities
• Provide biology-driven insights into payload mechanism of action, tumor context, therapeutic index, and combination strategies
• Design and guide experimental strategies to assess ADC activity, selectivity, resistance mechanisms, linker stability, and payload‑related pharmacology
• Contribute to next‑generation ADC platform strategy, including differentiated payload‑linker concepts and biology‑aligned ADC design
• Represent payload/linker expertise in cross‑functional teams, governance discussions, and external collaborations
• Monitor scientific, clinical, competitive, and IP landscapes related to ADC payloads, linkers, and emerging targeted modalities
• Mentor scientists and support a collaborative, high‑performing research environment

• Ph.D. in cancer biology, pharmacology, chemical biology, biochemistry, medicinal chemistry, bioengineering, or related discipline
• 5–10 years of industry experience in ADC discovery, targeted therapeutics, or oncology drug discovery
• Extensive expertise in ADC payloads (MoA, potency, resistance biology, therapeutic index)
• Strong knowledge of linker and conjugation technologies (stability, release mechanisms, site‑specific conjugation, develop ability)
• Deep understanding of ADC biology (tumor targeting, internalization, trafficking, payload release, bystander effects, pharmacology)
• Ability to integrate biology, chemistry, and translational data into actionable strategies
• Proven experience leading cross‑functional scientific discussions and influencing program direction
• Strong communication, collaboration, and leadership skills

Salary expected range: $152,600–$283,400 USD annually; performance‑based cash incentive; potential eligibility for annual equity awards; comprehensive US benefits package and time off.