Senior Associate Scientist II

Duties

• Manage database and serve as primary liaison for mRNA requests across research and program teams.
• Independently execute mRNA production at various scales (plate-based high-throughput with automation through lab scale to clinically representative GLP toxicology batches) and provide technical oversight as Person in Plant for GMP manufacturing.
• Contribute to guide RNA production across sites and scales (research, process scale, GMP).
• Collaborate with Analytical and QC teams to align testing and release workflows; track and communicate batch status, material availability, and testing timelines.
• Execute experiments and batch runs to generate IND/BLA supporting data for liver-targeted and partnered programs.
• Perform statistical/advanced analytics on experimental data; produce graphs for CMC and IND/BLA filings.
• Plan and execute process improvements and cost-saving initiatives, including raw material evaluation.
• Perform IVT, capping, and purification (including AKTA-based chromatography); design/support analytical method development.
• Apply DOE to optimize reaction conditions and interpret results using advanced analytics.
• Operate automated systems for plate-based mRNA production and sample processing (e.g., Lynx, Big Tuna, ResolveX, Tecan, Hamilton) and train peers.

• Bachelor’s degree in Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, or related field (or foreign equivalent) plus 5 years drug substance process development.
• 2 years analytical assay development.
• 4 years enzymatic process development for mRNA production using DoE.
• 5 years downstream processing with emphasis on chromatography of biologics/RNA (AKTA or similar; scaled down, automated systems).
• 1 year synthesis/purification of long guide oligonucleotide RNA.
• 3 years high-throughput/automation development, programming, and execution (Tecan/Hamilton/Lynx or similar).
• 4 years analytical characterization (HPLC/UPLC, TEM, DSC, UV-Vis, fluorescence spectrophotometry, plate ELISA).
• 5 years maintaining technically accurate research/experimental records.
• 2 years manufacturing batch documents and analytical methods development SOPs; preparing IND/CTA technical reports.

$103,500/year–$115,000/year.

Resumes to:
Human Resources,