Senior Associate Scientist - Discovery Research, Regeneron Cell Medicines

As a Senior Associate Scientist, typical day responsibilities include:

• Contribute to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications.
• Characterize genetically modified primary human T cells via immunophenotyping using multi-color flow cytometry and molecular assays (PCR, library preps for NGS, RNA-Seq).
• Develop and perform immunological functional assays to assess immune cell activation, anti-tumor cytotoxicity, proliferation, and cytokine secretion to evaluate CAR/TCR T-cell therapeutic efficacy.
• Design experiments independently and contribute to project direction.
• Maintain an electronic lab notebook and document experiment results.
• Review and present research data to the functional team.

• Have a can-do attitude, are curious, and excel in creative problem solving.
• Can multi-task, manage time well, and adapt quickly to new research areas and techniques independently.
• Are scientifically rigorous, highly organized, and a self-starter with strong attention to detail.
• Have strong verbal and written communication skills.

• BS/MS in immunology, cell biology, or related field; 3+ years of relevant experience.
• Experience working in a biotech/pharmaceutical industry.
• Strong understanding of immunology and cancer biology.
• Extensive experience isolating primary human immune cells and mammalian cell culture, including primary human T lymphocytes.
• Experience with in‑vitro immunological studies and functional T-cell assays using multi‑color flow cytometry, ELISA, and cytotoxicity assays.
• Gene delivery into T cells or tumor cells (lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation) is a plus.
• Molecular biology techniques (PCR, qPCR, Westerns, NGS/RNA-Seq library preps) are advantageous.