Senior Associate Scientist Cambridge Crossing - MA - US R1604241 Posted

Position: Senior Associate Scientist Cambridge Crossing - MA - US R1604241 Posted a day ago
## Senior Associate Scientist Cambridge Crossing - MA - USFind out how well you match with this job
** Working with Us
** Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:
** Position Summary
** We are seeking a highly motivated Senior Associate Scientist to join our Discovery Biotherapeutics organization in Cambridge, MA. This role will help advance high throughput, automated mammalian antibody expression capability within Discovery Biotherapeutics. The Senior Associate Scientist will operate automation‐enabled platforms that accelerate antibody discovery and engineering, including complex and multispecific biologics.

Working at the interface of mammalian expression biology, laboratory automation, and software enabled workflows, this position enables scalable, integrated discovery approaches that increase speed and impact across early biologics programs. This lab-facing role offers an exciting opportunity to make a meaningful scientific contribution in support of BMS’s mission of delivering innovative medicines to patients.

Experience in protein production and purification is required for this role as well as the ability to operate, troubleshoot, and help develop novel automation systems and solutions. A background in AKTA/Unicorn programming and liquid handler operation will be helpful, but the candidate must have a strong interest in automation and a proven track record of innovation and problem solving.
** Key Responsibilities
*** Strong background in molecular biology ie primer design, cloning, sequence analysis, and HT-PCR is required.
* Discovery-stage mammalian expression of antibodies and antibody-derived formats, including IgGs, fragments, and multispecific biologics in HT-plate based workflows.
* Experience with high-throughput, automated expression and purification workflows: 4mL through 100mL scale and QC analytics for protein production including A280 protein concentration measurements, CE-SDS, SDS-PAGE, HT-anSEC, and endotoxin testing.
* Background using liquid handling systems such as Lynx 1800, Biomek i7 or equivalent and familiarity with plate-based purification schemes.
* Experience working with automation teams to integrate liquid handling, incubators, culture handling, and downstream processing steps is a bonus.
* Interface with laboratory software platforms to ensure high-quality, traceable data generation compatible with computational and ML-driven discovery. Software includes Benchling, Geneious Prime, Electronic notebook documentation.
* Collaborate with AI/ML, binder discovery, molecular interaction, and functional assay teams to support binder discovery campaigns.
* The willingness to learn new workflows and work in mid-scale production / purification is desirable.
** Qualifications & Experience
*** BS with 4+ years; or MS with 2+ years of pharmaceutical R&D or related industry experience.
* Molecular biology background with a strong understanding of cloning and high throughput fragment DNA generation.
* Experience with HTP-scale and mid-scale protein production and operating high-throughput, automated expression workflows.
* Hands on experience in the operation and control of AKTA chromatography workstations and liquid handling systems like Lynx 1800 and Biomek i7.
* Experience in mammalian antibody expression, purification and ability to troubleshoot standard purification protocols…