Scientist Nucleic Acids Computational Biology

Job Summary

We are seeking a highly motivated and innovative scientist to drive advances at the interface of RNA biology, computational modeling, and machine learning. In this role, you will design and implement cutting‑edge computational approaches to uncover RNA structure–function relationships and support discovery and development programs across the organization. You will build computational tools that provide high‑throughput, data‑driven insights to accelerate next‑generation mRNA medicines.

• Build and implement custom mRNA optimization strategies to fine‑tune expression, stability, immunogenicity, and function of the RNA payload.
• Innovate on mRNA designs using scientific literature to implement novel design principles.
• Collaborate within the RNA sciences team to generate and analyze NGS data from RNA structure probing and other RNA biology–directed experiments such as SHAPE‑MaP, DMS‑MaP, ribosome profiling, RIP‑seq, etc.
• Lead cross‑functional collaboration with experimental biologists, molecular biologists, and therapeutic project teams to design studies, set experimental priorities, and validate computational discoveries.

• Bachelor’s degree with 5+ years of academic/industry experience.
• Or Master’s degree with 3+ years of academic/industry experience.
• Or PhD with no experience required.

• PhD +1 year in Computational Biology, Physics, Computer Science, or related field.
• Experience with diverse RNA sequencing modalities beyond standard RNA‑seq (e.g., ribosome profiling, CLIP‑seq, single‑cell RNA‑seq, SHAPE‑seq, spatial transcriptomics).
• Experience applying AI/ML models to NGS datasets to elucidate RNA biology.
• Experience utilizing computational modeling to evaluate nucleic acid functions.
• Strong knowledge of RNA secondary structure prediction concepts and computational tools.
• Proficiency in Python and/or R.
• Experience with cloud computing platforms and high‑performance computing environments.

Cambridge, MA, US: $141,150 – $171,042. The starting compensation range is for a full‑time employee. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final compensation will be decided based on demonstrated experience.

• Health coverage: medical, pharmacy, dental, and vision care.
• Well‑being support: BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs.
• Financial well‑being: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Paid time off, including unlimited time off with manager approval for exempt employees, company shutdown for holidays, and flexible time off.

We value diversity and do not discriminate based on race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process.