Senior Analytical Chemist - Solid State Characterization

Job title
:
Senior Analytical Chemist - Solid State Characterization

Location:

Cambridge, MA

Sanofi is seeking a highly motivated individual to join our analytical group as a Senior Scientist for Solid State Characterization. The group is part of the synthetic platform within Global CMC Development that is striving to become an industry leader in the development of transformative medicines.

The primary responsibility of this solid‑state characterization expert position is to lead and implement polymorphism and salt studies and act as the solid‑state representative on development projects.

Join the engine of Sanofi’s mission – where deep immunoscience meets bold, AI‑powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

• Lead and perform polymorphism studies for synthetic molecules, including polymorph screening, in‑depth physical characterization and thermodynamic assessment.
• Design and conduct salt selection studies (salt screening, in‑depth physical characterization and stability assessment).
• Act as the solid‑state representative on development projects to deploy solid‑form selection strategy in collaboration with other functions (e.g., Crystallization, Biopharm, and Chemistry).
• Develop and implement analytical methods using equipment including XRPD, DSC, TGA, SEM, Raman, IR, and laser granulometry.
• Provide physical characterization support (e.g., XRPD, PDS) to internal partner teams.
• Use computational tools to perform crystal structure prediction studies.
• Generate technical reports independently.
• Develop effective collaborations with others within project teams and between analytical groups.
• Introduce innovative analytical approaches to facilitate optimal decision‑making, including automation and AI/modeling integration.
• Promote scientific excellence through internal and external presentations and publications.

• PhD in chemistry, pharmaceutical science, material science, or related fields with a minimum of 3 years of postdoctoral experience in a pharma or biopharma environment.

• In‑depth experience with solid‑state characterization instruments: XRPD, DSC, TGA.
• Expertise in polymorphism and salt selection and understanding of powder and particle properties.
• In‑depth understanding of pharmaceutical solid‑state properties.

• Experience with SEM, Raman, IR, or laser granulometry.
• Demonstrated expertise in crystallography and computational prediction.
• Experience in crystal structure resolution by sc‑XRD.
• Experience in crystallization of synthetic molecules (e.g., crystallization process, single‑crystal growth).
• Having an established scientific network in the industry and academia.

• Good oral and written communication skills and ability to communicate effectively in individual and group settings.
• Ability to collaborate effectively in a multi‑disciplinary team environment.
• Record of adhering to and promoting lab safety practices.
• Open‑minded, agile, and capable of innovating in a complex environment.

• Bring the miracles of science to life alongside a supportive, future‑focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well‑crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high‑quality healthcare, prevention and wellness programs and at least 14 weeks’ gender‑neutral parental leave.
• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real‑world needs.
• Help improve the lives of millions of people globally by making drug development quicker and more effective.
• Work at the forefront of drug discovery, harnessing cutting‑edge AI, data, and digital platforms to push the boundaries of science.

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