Principal Research Scientist ; Analytical R&D LNP and Molecule
Listed on 2026-07-14
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Research/Development
Research Scientist, Pharmaceutical Science/ Research, Drug Discovery, Biotech Research
Job Description
For the Principal Research Scientist I position, we are seeking a highly motivated, experienced analytical scientist to be an Analytical Project Leader in New Chemical Entities (NCEs) drug substance and drug product in both preclinical and clinical programs. The candidate should have extensive expertise within an R&D environment with a fit for purpose mindset. Expectation includes expertise with synthetic molecules in solid oral dosage forms, and additional experience with lipid nanoparticles highly desired.
The qualified candidate must conceive, execute and communicate novel strategies that achieve project goals and mandate imperatives across a multi‑disciplinary research and development organization. Must have experience as an analytical project lead and demonstrate a capability to manage CMC deliverables relevant to early‑phase clinical development and discovery programs with pre‑clinical candidate compounds.
The qualified candidate must foster productive collaborations within the global Analytical R&D organization and with cross‑functional partners such as Discovery, Pre‑Clinical Safety, Process Chemistry, Process Engineering, Molecular Profiling and Drug Delivery, Drug Product Development, and Quality Assurance and CMC‑Regulatory.
The qualified candidate will be based at the Abb Vie Bioresearch Center in Worcester, MA and must be able to provide 50% on‑site support at Worcester and 50% on‑site support at the Abb Vie Cambridge Crossing site in Cambridge, MA according to project needs.
Responsibilities- Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to advise the selection of molecules with properties suitable for development.
- Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances or competitive threats and respond with appropriate new strategies.
- Demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
- Embrace the ideas of others, nurture innovation and manage innovation to reality.
- Raise the bar and is never satisfied with the status quo.
- Understand and comply with Abb Vie safety, quality and regulatory policies and government regulations.
- Bachelors, Masters, or Ph.D. in Analytical Chemistry typically with a minimum of 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
- Strong technical background in analytical chemistry, excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
- Demonstrated leadership with solving technical challenges across therapeutic modalities, specifically the lipid nanoparticle (LNP) and small molecule spaces.
- Demonstrated experience with a variety of mass spectrometry (MS) instrumentation and applications for structure elucidation and trace quantitation is highly desired.
- Fundamental understanding and working knowledge of various analytical techniques including HPLC, UPLC, GC, DSC, TGA, DVS, PXRD, NMR, dissolution.
- Familiarity with the role that physicochemical properties play in drug delivery and formulation design.
- Working knowledge of typical formulation approaches and routes of administration (i.e. IV, SC, IP, PO) across multiple species.
- Knowledge of preclinical and clinical formulation development principles relevant to lipid nanoparticle formulations.
- Demonstrate creative out‑of‑the‑box thinking to solve difficult problems.
- Self‑motivated, hard‑working, detail‑oriented individual able to work in a fast‑paced team environment.
- High‑quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our long‑term incentive programs.
Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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