Principal Scientist - Formulation

Job Title:

Principal Scientist I/II
•

Location:

Cambridge, MA (Onsite)

As a Principal Scientist, you will lead and execute formulation development and characterization strategies for complex biologics, including monoclonal antibodies (mAbs), multispecifics, antibody‑drug conjugates (ADCs), and other modalities. You will work closely with a team of more than ten associates, driving scientific excellence while fostering a culture of collaboration, integrity and innovation aligned with Novartis values. This position offers broad exposure to diverse biologic modalities and opportunities to contribute both experimentally and strategically.

• Design and execute formulation screening strategies for large‑molecule therapeutics, with emphasis on mAbs and related biologic modalities.
• Lead studies to identify stable formulations and communicate results to cross‑functional R&D teams.
• Manage team resources, timelines and deliverables with a strong customer‑focused mindset.
• Provide leadership, mentorship and direction to team members as the functional manager.
• Promote a safe, inclusive and collaborative environment while engaging stakeholders across biologics discovery and technical development.
• Partner with CMC teams to advance clinical candidates, finalize clinical formulations and support drug product process development.
• Develop stabilization strategies for liquid, frozen and lyophilized drug product formats for clinical development.
• Apply and interpret biophysical and analytical methods, including DSC, DLS, UV‑Vis, turbidity, subvisible particle analysis, viscosity, SEC and HIC.
• Work with automation teams to implement high‑throughput formulation screening and physicochemical characterization across discovery, optimization and early development.
• Operate analytical instrumentation, analyze data, maintain ELN documentation and author technical reports.
• Contribute to data interpretation, scientific presentations and cross‑functional discussions within the global BRC community.

• PhD in biochemistry, biotechnology, chemistry or a related field with at least two years of relevant industry experience.
• Proven experience leading, coaching and developing scientific teams.
• Hands‑on expertise in protein formulation and assessment of biophysical properties of the molecule (e.g., DLS, viscosity, thermal and colloidal stability).
• Strong background in developing strategies for formulations for large‑molecule therapeutics, with understanding of early‑stage development workflows.
• Experience designing and executing preformulation studies and interpreting stability‑indicating assays (e.g., SEC, CE, charge variants, MS).
• Demonstrated problem‑solving skills, scientific curiosity and ability to work independently.
• Excellent communication, organizational and multitasking skills.

• Knowledge of viral vector‑based gene therapy (AAV, LVV) formulation and characterization.
• Familiarity with DoE tools (e.g., JMP) for high‑throughput experimental design.
• Experience working with automated liquid handling systems.

The salary for this position is expected to range between $108,500 and $201,500 per year for Principal ScientistI, and between $119,700 and $222,300 per year for Principal Scientist II. The final salary offered is determined based on factors such as relevant skills and experience, and will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Compensation will include a performance‑based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US‑based eligible employees receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. Employees are also eligible for a generous time‑off package including vacation, personal days, holidays and other leave.