Senior Scientist, Pharmacology

Arbor Biotechnologies™ a next-generation gene editing company based in Cambridge, MA is advancing a pipeline of novel gene editing therapeutics to address a wide range of genetic conditions – from the ultra-rare to the most common genetic diseases. The company’s unique suite of optimized gene editors goes beyond the limitations of early editing technologies to unlock access to new gene targets and has fueled a robust pipeline of first-in-class assets focused on diseases of high unmet need.

With Arbor’s lead program, ABO-101 for the treatment of primary hyperoxaluria type 1, progressing into clinical trials, the company continues to focus their research and development efforts on genomic diseases of the liver and CNS for which there are no existing functional cures. For more information, please visit: arbor.bio.

You’re driven by purpose and fueled by curiosity. You take ownership, think boldly, and stay resilient through challenge. You lead with humility, value diverse perspectives, and put the success of the team above personal recognition.

That’s who thrives  this resonates, read on.

The Senior Scientist , Pharmacology willbe a hands-on scientific leader within Arbor’sneurosciencegene-editing programs, driving the strategy, design, execution, and interpretation of in vivo pharmacology studies. Reporting to the Associate Director, In Vivo Pharmacology, this person will collaborate across functions and with external CRO partners to generate decision-enabling data that support advancement of neuroscience programs. This role is based in our Cambridge office, with an expectation of on-site presence 4-5 days per week.

• Serve as pharmacology lead in cross-functional nonclinical teams
• Design and execute in vivo pharmacology studies for neuroscience gene-editing programs
• Analyze and interpret in vivo gene editing data, including molecular biology and histology readouts
• Manage 1-2 research associates, providing scientific guidance, prioritizing work, and supporting their development
• Prepare study reports and summaries for regulatory filings
• Oversee CRO studies to ensure high-quality, timely deliverables

• PhD or equivalent degree in Pharmacology, Neuroscience, Genetic Medicine, Biomedical Sciences, or a related field
• 2-5 years of industry experience designing, managing, and interpreting in vivo pharmacology studies for neuroscience indications
• Experience with AAV-based therapeutic programs
• Expertise in molecular readouts, including DNA-, RNA-, and/or protein-based assays
• Experience overseeing outsourced studies, collaborating with CRO partners, and ensuring high-quality, timely deliverables
• Experience managing or mentoring junior scientists or research associates
• Experience preparing study reports or summaries to support regulatory filings
• Ability to work independently and collaboratively in a fast-paced, matrixed team environment
• Strong planning, organization, time management, communication, and interpersonal skills

• Experience with gene editing and/or ALS therapeutic programs
• Experience with non-human primate biodistribution studies and/or IND-enabling studies
• Histology experience, including ISH and/or IHC

• Purposeful Action: Driven by outcomes, guided by purpose
• Bold Resilience: Speak boldly, embrace change, grow forward
• Humble Authenticity: Be real, value the uniqueness of others, elevate all

The anticipated salary range for candidates for this role will be $XX - $XX. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, industry knowledge, technical skills, and other factors that may prove relevant during the interview process.

We promote diversity and inclusion not just in our recruitment processes, but in everything we do. We’re an equal opportunity employer and we will continue to ensure our recruitment process is free of bias and our workplace is inclusive, positive, and free of discrimination and respecting of all backgrounds and beliefs.