Scientist, LNP Process and Development Cambridge, MA

Serif Biomedicines is a privately held, early-stage biotechnology company pioneering Modified DNA as a new class of medicines. Modified DNA brings together the best features of mRNA and gene therapy, while mitigating their limitations, by enabling medicines that are durable, redosable, programmable, and scalable. Serif was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.

Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines (GENB), Seres Therapeutics (MCRB), Tessera Therapeutics, and Lila Sciences.

We are seeking a highly motivated Scientist to support the development and scale-up of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role will focus on process optimization and scale-up of targeted LNPs encapsulating modified DNA and cofactor mRNA, while also contributing to research efforts aimed at improving LNP design and performance.

This is an ideal opportunity for a scientist with a strong background in process development who is interested in expanding into formulation development and early-stage R&D, including formulation screening and optimization of next-generation LNP systems.

The successful candidate will work collaboratively within cross‑functional teams to advance LNP platform capabilities and support the development of scalable and robust nucleic acid delivery systems.

• Support process development and optimization activities for LNP formulation and scale‑up, including mixing parameters, encapsulation efficiency, and reproducibility.
• Design and execute experiments to improve the performance and manufacturability of LNPs encapsulating modified DNA and mRNA.
• Collaborate with internal and external teams to support characterization and evaluation of LNP formulations.
• Assist with technology transfer and scale‑up activities, including coordination with external partners or internal manufacturing teams.
• Analyze and interpret experimental data, maintain accurate documentation, and communicate findings to project teams.
• Stay current with advancements in LNP technologies and nucleic acid delivery approaches.

• PhD. in Chemical Engineering, Pharmaceutical Sciences, Bioengineering, or a related field, with 3+ years of relevant industry experience; M.S. with 8+ years of experience; or Bachelor with 10+ years of experience.
• Strong background in process development, scale‑up, or manufacturing of nanoparticle or LNP‑based systems.
• Experience working with nucleic acid formulations (e.g., mRNA, DNA) is highly preferred.
• Familiarity with T mixing, or similar, formulation scale‑up, and characterization techniques (e.g., DLS, encapsulation assays).
• Demonstrated ability to design experiments, analyze data, and solve complex technical problems.
• Strong communication and collaboration skills.

• Opportunity to work at the forefront of LNP formulation innovation
• Collaborative, science‑driven culture with high impact research
• Competitive compensation and benefits package

Salary range for this role is $100,000 – $143,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID‑19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving…