Senior Principal Scientist

About the Role

We are seeking a highly motivated Senior Principal Scientist to spearhead the execution and expansion of our mast cell disorders Research & Development pipeline. A successful candidate will have deep expertise in hematopoietic stem cell biology with a particular focus on mast cell disorders and related immune disorders in the context of rare diseases. This individual will work cross‑functionally to identify and shepherd early‑stage programs into the research pipeline, through internal and external innovation, and ensure the successful progression of development‑stage programs through the clinic to registration by providing deep research subject‑matter expertise.

In parallel, the candidate will build relationships with key opinion leaders in the field, source disease‑relevant cell lines, models, and patient samples, and work with research and translational sciences to expedite internal research and accelerate later‑stage programs.

Location: Cambridge, MA

• Serve as subject‑matter expert for mast cell disorders and related rare immune and hematologic conditions, providing scientific leadership and strategic guidance.
• Drive early discovery initiatives by directing target identification, mechanistic biology research, and preclinical strategy development for first‑in‑class and best‑in‑class rare‑disease therapeutics.
• Initiate and lead new preclinical programs to strategically expand the rare‑disease pipeline and advance innovative treatment options.
• Identify and leverage cross‑portfolio synergies with rare blood disorders and hematopoietic stem cell programs to maximize therapeutic opportunities and optimize resource allocation.
• Monitor the competitive landscape and establish strategic partnerships through targeted academic collaborations and business‑development initiatives.
• Partner cross‑functionally with Clinical and Business Development teams to develop indication expansion and lifecycle‑management strategies, supporting comprehensive portfolio development from discovery through commercialization.
• Contribute to organizational excellence through strategic planning, executive communications, scientific publications, and regulatory submissions that advance company objectives.

• Earned Ph.D. in molecular biology, cellular biology, hematology, immunology, or related discipline with at least 7 years of research experience in a biopharmaceutical setting.
• Experience in hematopoietic stem cell and mast cell research, including systemic mastocytosis.
• Experience in early‑ and late‑stage research.

• Track record of scientific publications and external visibility (e.g., scientific publications, conference presentations).
• Experience in translational research and drug development.
• Strong network of research and clinician colleagues to leverage for collaboration and insight.
• Strong understanding of emerging science, leading therapeutic approaches, and competitive landscapes for HSC and mast cell disorders, particularly in the rare‑disease space.
• Familiarity with a broad range of cell‑based and animal models of HSC and mast cell disorders and relevant readouts.
• Familiarity with a wide range of therapeutic modalities including biologics, small molecules, and/or genomic medicines.
• Familiarity with computational biology and a broad range of omics.
• Experience managing studies at CROs.
• Experience drafting regulatory documents to support IND or CTA applications with agencies such as the FDA and EMA.

• Ability to weigh and integrate inputs and opinions from a broad range of stakeholders with diverse backgrounds.
• Ability to capture and distill complex data, concepts, and information into clear, well‑articulated messages to guide and drive decision‑making.
• Ability to multi‑task and adapt to rapidly changing priorities and deadlines.
• Excellent critical thinking, analytical, and problem‑solving skills.
• Excellent written and oral communication skills, with the ability to communicate effectively in multidisciplinary teams as well as to senior leadership.
• Strong interpersonal skills, with the ability to build excellent working relationships.