Director of Chemistry, Molecule Process Development and Manufacturing

About This Role

We are seeking a highly motivated and creative Director of Chemistry to join our Small Molecule Chemical Development team. In this role, you will lead and mentor scientific and engineering teams as you guide project progression from early‑phase through late‑phase drug development. You will oversee the design and refinement of robust manufacturing processes for a wide range of small molecules, supporting pre‑clinical and clinical therapeutics.

This role is integral to advancing our scientific endeavors, driving innovation, and enabling the successful launch of new medicines through collaborative, safe, economical, and sustainable process development.

We are a team of organic chemists and chemical engineers engaged in the design of innovative processes that supply new medicines to patients. We focus on developing safe, economical, sustainable, cost‑effective, and robust processes to support clinical trials and launch of new medicines across various drug modalities. We are driven by first‑principles science, data‑driven decision‑making, and collaborative teamwork.

• Lead collaborative development and manufacturing teams to design and conduct experiments that optimize and characterize the processes of Biogen assets, emphasizing process understanding, robustness, and productivity.
• Design, guide, and execute experimental plans to advance the Biogen portfolio and implement safe, efficient, and robust chemical processes for Biogen drug candidates.
• Collaborate with development and manufacturing teams to support transition of chemical and biochemical processes from laboratory scale to manufacturing partners.
• Work with Process Engineering, Analytical Chemistry, Oligo Synthesis, Solid Form, and Separations colleagues to develop knowledge and controls needed for the supply of clinical materials and regulatory filings.
• Communicate project research results effectively through reports and discussions in team meetings, including authoring the CMC section of INDs.
• Interact with Contract Research Organizations as project needs evolve, which may include travel.
• Initiate innovative research projects to improve fundamental understanding and control of Biogen processes.

• You have a passion for exploring scientific concepts and are eager to contribute to the design, development, and execution of cutting‑edge technologies in the service of delivering drug candidates for clinical trials.
• You thrive in a collaborative environment where urgency, accountability, inclusion, and integrity are shared values.
• M.S. or Ph.D. with 12+ years of relevant experience, including people management in pharmaceutical or biotech settings.
• Strong background in the theory and practice of pharmaceutical process chemistry and engineering, including synthetic strategies, impurity controls, analytical, purification and isolation techniques, process characterization, process safety, and tech transfer protocols.
• Demonstrated experience leading project teams involved in delivery of APIs across several modalities.
• Excellent communication and interpersonal skills, with a desire to work in a highly collaborative team environment.

• Experience engaging with external partners and representing the organization in external-facing settings.
• Familiarity with regulatory requirements and CMC activities related to drug development.

Base compensation range: $‑$. Base salary is determined through an analytical approach that considers relevant skills, experience, job location, and internal equity.

• Short‑term and long‑term incentives, including cash bonuses and equity opportunities.
• Comprehensive benefits package for employees and families: medical, dental, vision, life insurance, fitness and wellness programs, short‑ and long‑term disability insurance.
• Minimum 15 days paid vacation, December 26‑31 shutdown, 12 company‑paid holidays, 3 personal days off, 80 hours sick time, paid maternity and parental leave.
• 401(k) with company match, employee stock purchase plan, tuition reimbursement up to $10,000 per year.
• Employee Resource Groups participation.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information, or any other basis protected by federal, state, or local law. Biogen is an E‑Verify Employer in the United States.