Postdoctoral Fellow

Postdoctoral Fellow

In this vital role you will generate mechanistic insights that directly influence analytical control strategy, molecule design, and formulation development across Amgen's pipeline.

• Generate mechanistic insights that directly influence analytical control strategy, molecule design, and formulation development across Amgen's pipeline.
• Design and execute MS-based mechanistic studies of protein fragmentation pathways in biologics, including stable-isotope solvent-labeling approaches such as D₂O and H₂¹⁸O oxygen-incorporation experiments to distinguish hydrolytic, enzymatic, and chemical fragmentation mechanisms.
• Apply advanced analytical characterization techniques, including mass spectrometry, chromatography, and structural analysis, to identify fragmentation products, map fragmentation sites and characterize reaction intermediates.
• Integrate experimental data with mechanistic and statistical modeling to improve prediction of degradation behavior.
• Translate mechanistic findings into testable hypotheses and practical mitigation strategies, including molecule design (sequence selection), formulation considerations, and storage recommendations.
• Publish findings in high-impact peer‑reviewed journals and contribute to intellectual property generation.
• Present research internally and externally at scientific conferences.

• PhD at time of appointment

• PhD at the time of appointment in Analytical chemistry, physical chemistry, or related life sciences disciplines
• Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first‑author publication(s)
• Demonstrated expertise with Chem Draw and mechanistic biomolecular chemistry, including the ability to propose, illustrate, and evaluate reaction mechanisms relevant to protein and peptide degradation pathways
• Strong understanding of protein chemistry, protein degradation pathways, peptide mapping, and biologics analytical characterization
• Experience with LC‑MS/MS, high‑resolution mass spectrometry and advanced protein characterization
• Excellent critical thinking, organizational, and communication skills
• Passion to learn and work collaboratively within a large team of scientists with diverse technical and cultural backgrounds

• Comprehensive employee benefits package including a retirement and savings plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• Discretionary annual bonus program and stock‑based long‑term incentives
• Award‑winning time‑off plans and flexible work models where possible

81,178.40

USD – USD

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Please contact us to request accommodation.