Associate Scientist II, Oligonucleotide Synthesis

Overview

We are looking for a talented and highly motivated Associate Scientist II to join our RNA synthesis group and support our mission to deliver the next generation of RNAi‑based medicines. The successful candidate will contribute to the synthesis, purification, and analysis of oligonucleotides in support of our growing RNAi drug development platform. In addition, they will expand the chemical repertoire of RNAi therapeutics through the synthesis, purification, and characterization of chemically modified oligonucleotides.

This position is onsite and will be primarily located in Cambridge, MA.

• Design and execute high‑throughput synthesis of modified oligonucleotides using automated platforms
• Carry out the downstream purification and analytical characterization of the synthesized oligonucleotides using instrumentation such as HPLC, LC‑MS, UV‑Vis
• Optimize and/or develop new synthetic methods to expand our synthetic capabilities
• Effectively troubleshoot synthetic/process issues and independently find solutions
• Analyze and interpret data to improve yield, purity, and process efficiency
• Maintain and troubleshoot essential lab equipment, coordinating servicing and repairs as needed
• Maintain clear, accurate, and timely experimental documentation
• Effectively work with team members to foster communication, culture, and efficiency

• Bachelor's in chemistry or a related discipline with 0‑3 years of relevant experience, preferably in an industrial setting. Alternatively, Master's in Chemistry or a related discipline with 1+ years of relevant experience, preferably in an industrial setting
• Prior experience with solid‑phase synthesis (SPS) of oligonucleotides with deep understanding of the mechanisms and processes involved in SPS is a plus
• Experience with analytical instrumentation including HPLC (anion‑exchange and reverse‑phase), LC‑MS, and UV‑Vis
• Familiarity with laboratory automation (e.g., liquid handlers) is a plus
• Strong troubleshooting and process optimization skills
• Excellent written and oral communication skills, good organization, multitasking ability, and the ability to work within a team and independently are required
• Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment

$67,600.00 – $

The pay range reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity).

Alnylam offers comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts, a 401(k) with a generous company match, paid time off, wellness days, holidays, and two company‑wide recharge breaks.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law.

Alnylam is an E‑Verify Employer.