Discovery Postdoctoral Fellow, Spatial Transcriptomics - Neuroscience

We are excited to invite applications for the Novartis Biomedical Research Postdoctoral Fellowship Program, a unique training opportunity designed for exceptional early-career scientists eager to tackle some of the most challenging problems in biomedical research and drug discovery. As a Postdoctoral Research Fellow, you will join Neuroscience in Cambridge and pursue an innovative research project at the front of biomedical science and drug discovery.

You will work alongside leading scientists in a highly collaborative, multidisciplinary environment while gaining exposure to the broader ecosystem that translates scientific discovery into medicines. Our fellows are empowered to ask bold scientific questions, apply cutting-edge technologies, and develop approaches that have the potential to transform patient care.

Internal

Job Title:

Discovery Postdoctoral Fellow

Position Location:

Cambridge, MA, onsite

• Novartis is unable to offer relocation support for this role: please only apply if this location is accessible for you.
• This position is not eligible for visa sponsorship. Please only apply if you are currently authorized to work in the US for the 3 year duration of the program.

This is a full-time training position of up to three years in duration.

The Postdoctoral Fellow will leverage spatial transcriptomics, advanced bioinformatics, CRISPR engineering, and human iPSC-based functional assays to discover and validate novel therapeutic targets for amyotrophic lateral sclerosis (ALS) at the neuroimmune interface.

The Novartis Biomedical Research Postdoctoral Fellowship Program is designed to develop the next generation of scientific leaders and power the future of medicine through rigorous research, and immersive learning experiences, including the implementation of AI tools in biomedical research.

• Guidance from accomplished scientific leaders and subject matter experts
• Access to advanced technologies, platforms, and research capabilities
• Collaboration across disciplines and organizational boundaries
• A global and diverse community of postdoctoral fellows
• Dedicated programming designed to help fellows thrive throughout their careers
• Personalized experiential learning opportunities through a Postdoc Practicum that empower fellows to explore new scientific domains, build cross-functional expertise, and expand their impact beyond their primary research project
• Opportunities to present research, publish in leading journals, and build an international scientific network
• We are entering a new era of biomedical research breakthroughs through the convergence of biology, technology, and artificial intelligence tools, and fellows are also supported in engaging with these emerging approaches

This is a full-time training position of up to three years in duration.

At Novartis, our purpose is to reimagine medicine to improve and extend people’s lives. Through this program, you will grow as a scientist and future leader while contributing to discoveries that may ultimately benefit patients worldwide.

The start date for the 2026 Novartis   Postdoctoral Fellowship Program cohort is October 1, 2026. This is a full-time training position of up to three years in duration.

• Establish and apply high-resolution spatial transcriptomics workflows to profile disease-relevant regions in ALS model systems and identify spatially organized gene-expression programs.
• Develop and benchmark computational pipelines for spatial transcriptomic analysis, including spatial clustering, gene-module detection, ligand-receptor interaction mapping, and integration with single-cell and human ALS datasets.
• Generate and characterize CRISPR-engineered knockout or knock-in human iPSC lines for selected spatially identified target genes.
• Collaborate closely with multidisciplinary teams across neuroscience, functional genomics, bioinformatics, genome engineering, stem cell biology, and translational research.
• Communicate research findings through internal presentations, conference abstracts, and peer-reviewed publications.

• PhD (or equivalent doctoral…