Senior Scientist I

Senior Scientist, Mass Spectrometry/Protein Characterization

Make your mark for patients

To strengthen our Protein Sciences team in our Boston hub in Cambridge, MA, USA, we are seeking a talented individual to fill the position of Senior Scientist, Mass Spectrometry/Protein Characterization.

As a Senior Scientist, Mass Spectrometry/Protein Characterization, you will serve as the LC/MS subject matter expert within Protein Sciences. This laboratory-based position requires a proven ability in the acquisition and interpretation of LC/MS data from both intact protein and peptide mapping workflows. Working in a multidisciplinary team you will apply your expertise to complement the biophysical and biochemical characterizations of recombinant proteins and communicate to stakeholders across the US research organization.

You like to work in an environment where you can:

• Apply your advanced Mass Spectrometry expertise to drive the characterization of proteins across diverse protein classes (soluble and membrane).
• Use your strong communication skills to collaborate with scientific teams across the organization to advance drug targets.
• Provide support for complementary biophysical techniques, including analytical SEC, SEC-MALS, mass photometry, Fida Neo, NanoDSF, and additional methods as required. Experience in functional and biochemical assays is beneficial.
• Grow in your role to mentor direct reports, developing their expertise in experimental design and execution as well as guiding professional development.

You will contribute by:

• Characterizing recombinant proteins of different classes, including cytosolic, secreted, membrane and refolded proteins.
• Working hands-on in the lab, maintaining and overseeing LC/MS equipment.
• Applying your knowledge of current LC/MS technologies to innovate and drive proteomic and lipidomic workflows where applicable.
• Managing the workload and demands from multiple projects by communicating experimental results, advising on methods, troubleshooting and executing experiments.
• Supporting protein sciences team by exploring new technologies, contributing to annual budgets and strategies, and maintaining modern instrumentation in the laboratory.

Interested? For this position you'll need the following education, experience and skills:

Minimum Qualifications:

• PhD in related field and/or several years of industrial laboratory-based LC/MS experience (biochemistry, chemistry, molecular & cellular biology, or biophysics) + 6-12 years' experience, BS or MS + 12-18 years' experience.
• In-depth knowledge of Waters Connect and Thermo Scientific Xcalibur software
• Hands-on experience and responsibility for Thermo Orbitrap and Waters instrumentation coupled to UPLC systems
• Peptide mapping expertise and knowledge of PTMs
• Use of data analysis software packages for sequence mapping and intact mass deconvolution e.g. Protein Metrics Byos, Biopharma Finder, Proteome Discoverer or similar
• Knowledge of protein expression systems
• Troubleshooting and maintenance of LC/MS systems
• Excellent organizational, communication, record keeping, team-working abilities

Desirable experience:

• Experience with mass spectrometry data analysis of peptides and NCEs
• Experience with biophysical techniques within a multidisciplinary environment e.g. analytical SEC, SEC-MALS, mass photometry, Fida Neo, NanoDSF
• Knowledge of the drug discovery pipeline, including translational and clinical pharmacology as it relates to mass spectrometry analysis
• Managing or mentoring junior scientists

Salary:

This position's reasonably anticipated base salary range is $117,600 to $154,400 per year. The actual salary offered will consider internal equity and may also vary depending on the candidate's region, job-related knowledge, skills and experience, among other factors.

Are you ready to 'go beyond' to create value and make your mark for patients? If this sounds like you, then we would love to hear from you!

About us UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are over 9,000 people in all four corners of the globe, inspired by patients and driven by science.

Why work with us? At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected, and has equal opportunities to do their best work. We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees, or our planet.

Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.

At UCB, we've embraced a hybrid-first approach to work, bringing teams together in local hubs to foster collaborative curiosity. Unless explicitly stated in the description or precluded by the nature of the position, roles are hybrid with 40% of your time spent in the office.

UCB is an equal opportunity employer. All…