Principal Scientist, Antibody Discovery and Engineering
Listed on 2026-08-03
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Research/Development
Drug Discovery, Research Scientist, Biotech Research, Immunology Research
The Role
Moderna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First-in-Human studies. The Antibody Discovery team plays a central role in discovering, engineering, and optimizing antibody-based therapeutic molecules that enable new treatment strategies across Moderna's therapeutic pipeline.
This Principal Scientist will lead integrated antibody discovery and engineering campaigns across oncology and autoimmune disease programs. The role spans concept development through lead identification, including biological and therapeutic‑area research, target and antigen strategy, immunization and B cell discovery campaign design, antibody screening, sequence analysis, engineering, characterization, and optimization.
The successful candidate will bring deep expertise in therapeutic antibody discovery, antibody engineering, immune repertoire mining, display technologies, and molecular-format optimization. This individual will operate with a high degree of independence, scientific judgment, and cross‑functional influence while partnering with antigen design, structural and computational biology, Immuno‑oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners.
This is a hands‑on scientific leadership role for someone who thrives in a fast‑paced, innovative, and highly collaborative environment. The Principal Scientist will help shape differentiated antibody‑based therapeutics from early idea to therapeutic lead nomination, strengthen discovery strategy, and contribute to Moderna's next‑generation antibody capabilities.
Moderna is a smoke‑free, alcohol‑free, and drug‑free work environment.
The RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First-in-Human studies. The Antibody Discovery team plays a central role in discovering, engineering, and optimizing antibody-based therapeutic molecules that enable new treatment strategies across Moderna's therapeutic pipeline.
This Principal Scientist will lead integrated antibody discovery and engineering campaigns across oncology and autoimmune disease programs. The role spans concept development through lead identification, including biological and therapeutic‑area research, target and antigen strategy, immunization and B cell discovery campaign design, antibody screening, sequence analysis, engineering, characterization, and optimization.
The successful candidate will bring deep expertise in therapeutic antibody discovery, antibody engineering, immune repertoire mining, display technologies, and molecular-format optimization. This individual will operate with a high degree of independence, scientific judgment, and cross‑functional influence while partnering with antigen design, structural and computational biology, Immuno‑oncology and Autoimmune Therapeutics research leadership, project teams, and external CRO partners.
This is a hands‑on scientific leadership role for someone who thrives in a fast‑paced, innovative, and highly collaborative environment. The Principal Scientist will help shape differentiated antibody‑based therapeutics from early idea to therapeutic lead nomination, strengthen discovery strategy, and contribute to Moderna's next‑generation antibody capabilities.
Moderna is a smoke‑free, alcohol‑free, and drug‑free work environment.
Here’s What You’ll Do- Lead integrated antibody discovery and engineering campaigns from early concept through lead identification, optimization, and nomination.
- Develop discovery strategies that incorporate target and antigen evaluation, immunization design, B cell screening, display‑based engineering, sequence analysis, and data‑driven lead selection.
- Design, execute, and oversee antibody generation and optimization workflows, including immunizations, B cell discovery,…
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