Scientific - Research Scientist Research Scientist

Research Scientist – Discovery Biosciences, Oncology

Location:

100% onsite – Cambridge, MA (5 days per week) Duration: 7-month contract Payrate: $48/hr to $50.90/hr

Position Overview:

We are seeking a motivated and talented Scientist to join our Oncology Research and Development team on a 7-month contract basis. This role is heavily focused on wet lab work and will contribute to cutting-edge research projects aimed at understanding cancer biology, identifying client drug targets, and developing new therapeutic approaches. The successful candidate will work in a collaborative and dynamic environment alongside leading scientists in the field of oncology.

• Conduct full-time laboratory-based research supporting target identification, oncology drug discovery, and development.
• Execute a variety of molecular biology, cellular biology, and biochemical assays, including:
• Maintenance and manipulation of 2D and 3D cell cultures, including spheroids and organoids
• Lentiviral- and nucleofection-based gene transfer and genome editing
• Target gene perturbation using CRISPR/Cas9 and Cas
  12, shRNA, and siRNA
• Cell viability and cytotoxicity assays using Incu Cyte, Cell Titer-Glo, CyQUANT, and clonogenic assays
• Large-scale functional genetic and phenotypic screens
• RT-qPCR and western blot; sample preparation for RNA-seq
• Co-immunoprecipitation (coIP) and other protein interaction studies
• ELISA, Meso Scale Discovery (MSD), and other immunoassays
• Design, optimize, and troubleshoot complex cell-based assays to evaluate therapeutic candidates and understand cancer signaling pathways.
• Collaborate with cross-functional teams, including medicinal chemistry, bioinformatics, and in vivo pharmacology, to advance project goals.
• Analyze and interpret experimental data, maintain accurate and detailed lab records, and present findings in team meetings.
• Contribute to the preparation of technical reports, publications, and presentations.

• Bachelor's or Master's degree in Biological Sciences, Molecular Biology, Biochemistry, or a related field with extensive and demonstrated experience conducting oncology research in an academic or industry setting.
• Strong analytical and problem-solving skills, with attention to detail and the ability to troubleshoot experimental protocols.
• Ability to work independently and as part of a collaborative team.
• Excellent organizational skills, with the ability to manage multiple tasks and deadlines.
• Effective written and verbal communication skills.

• Extensive experience with oncology research, cancer biology, and drug discovery processes.
• Experience with advanced techniques such as high-content imaging and flow cytometry.
• Proficiency in data analysis software (e.g., Graph Pad Prism, Flow Jo) and familiarity with bioinformatics tools.