Senior Scientist, Conjugation Biochemistry

Senior Scientist, Conjugation Biochemistry

Cambridge, MA USA

In today's healthcare system, disease diagnosis often relies on invasive procedures, such as biopsies, which enable direct interrogation of cellular and tissue health at the suspected source of disease. Due to their invasiveness, cost, and general inconvenience to the patient, biopsies are often conducted after onset of symptomatic disease presenting one of the largest barriers to delivering interventions early in disease progression when they are likely to be most impactful.

Flagship Labs 103, Inc. is a privately held early-stage company that is building advanced technological and computational platforms to pioneer the detection of cellular dynamics from minimally invasive biospecimens that can be leveraged to connect individuals to the most effective interventions to prevent onset and progression of disease

We are seeking an experienced and motivated Senior Scientist to join and lead our conjugation efforts to drive FL103's programs forward. Ideal candidates will be self-motivated, independent, and committed to the generation of high-quality data within a fast-paced and innovative research team. The Conjugation Biochemist will support ongoing bioconjugation projects in several research and development areas.

• Design, synthesis, purification and analysis of oligonucleotide-conjugates on antibodies and other modalities. Develop and optimize conjugation protocols using established and novel chemistries and technologies as part of an assay development platform.
• Collaborate closely with the assay development team to guide and optimize conjugates to support FL103's programs.
• Work as part of a cross-functional team to manage and maintain progress against multiple project timelines, deliver routine updates, and communicate progress to the team.
• Establish and maintain excellent working relationships with critical collaborative partners throughout the company to advance discovery research activities to pre-clinical development.
• Contribute to the preparation of research reports and presentations for internal project teams, leadership team, and external audiences.
• Maintain updated and well-organized lab notebooks and batch records.

• Ph.D. in Biochemistry, Chemistry, or related scientific discipline
• 5+ years of bioconjugation-related industrial experience, preferably in designing, preparing, and validating oligonucleotide conjugates.
• Understanding project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.
• Strong problem-solving skills and a proactive attitude towards exploring new approaches.
• Demonstrates strong written and verbal communication skills, with the ability to clearly present complex scientific data to cross-functional and senior leadership teams.
• Hands-on expertise with current and cutting-edge bioconjugation techniques for antibodies, proteins, peptides, and other biomolecules.
• Demonstrated hands-on experience in analytical characterization of conjugates with a strong analytical mindset. Proficiency in purification techniques such as RP-HPLC, FPLC, SEC, and IEX.
• Able to work independently or in cross-functional team settings with minimal supervision.
• Adaptable and flexible, able to navigate shifting priorities and handle day-to-day challenges with professionalism and confidence in fast-moving environments.
• Self-motivated with strong interpersonal, organizational, and communication skills, and able to take a hands-on approach in a dynamic, fast-paced, and collaborative environment.