Associate Director, Translational Physician-Scientist

Associate Director, Translational Physician-Scientist

The Research Department at Alnylam is seeking a passionate and creative physician-scientist to join the Translational Research Group to play a key role in guiding the discovery, validation, and prioritization of new therapeutic targets. You will join a highly collaborative team of translational biologists, proteomics scientists, metabolomics scientists, physician-scientists, and data scientists to enhance the translation of basic discoveries in biology and human genetics to new medicines.

Our Research Department is a fast-paced and dynamic environment where promising new ideas rapidly progress to the clinic. This is an excellent opportunity for academic physician-scientists looking to transition into drug development. Working on-site in Cambridge, MA, you will collaborate across our Research, Early Development, and Clinical Research teams to drive programs from lead target identification through early-stage (Ph1/2) clinical trials.

Key Attributes and Responsibilities

• Integrate knowledge of medicine with insights from human data including genetics, natural history studies, and clinical trials to generate and vet novel therapeutic hypotheses.
• Play a leading role in identifying early translational and clinical key opinion leaders, driving scientific discussions, and building external relationships that support human sample sourcing and translational modeling.
• Evaluate the scientific rationale and clinical feasibility of indications for new targets, using medical knowledge to guide preclinical and translational strategy.
• Lead early biomarker strategy across multiple programs, collaborating with in-house data scientists, molecular biologists, and computational experts to align biomarker discovery with emerging clinical plans.
• Represent Translational Research across preclinical and clinical development, from lead target identification through Phase 2 clinical trials, by engaging key stakeholders, presenting to leadership, and contributing to trial design and biomarker discovery and development.

Qualifications

• Proven track record of putting basic sciences questions in a translational/clinical context.
• MD or MD/PhD with a strong foundation in a subspeciality with sufficient exposure to a breadth of rare and common diseases.
• Capacity to quickly synthesize the clinical trial landscape and contribute to trial design (prior industry experience is highly valued, but not required for a candidate with strong scientific fundamentals).
• Exceptional scientific communication skills with a proven ability to draft high-impact manuscripts, present to leadership, and independently balance long-term strategic projects with time-sensitive, fast-paced requests.
• Experience in academia or industry with human genetics, biomarker discovery, or therapeutic development.
• Familiarity with computational biology, bioinformatics, or working closely with statistical geneticists is a strong plus.

U.S. Pay Range $ - $

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being.

Nearest Major Market:
Cambridge Nearest Secondary Market:
Boston