Associate Director, Toxicology

About Parabilis Medicines

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets longconsidered undruggable.

The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigationalmedicine,zolucatetide, is the first and only direct inhibitorof theβ-catenin:

TCFinteraction,a central node in theWnt/β-catenin pathway that haseluded drug developers for decades.

Zolucatetideis being evaluated in the clinic across multiple

Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) anda rangeofothersolid tumor indications. Beyondzolucatetide,Parabilisis advancing additional

Helicon-based programs focused on other challenging targetswhere we believeourmedicines could have life-altering impact. For more information, visit (Use the "Apply for this Job" box below). follow us on Linked In.

Parabilis Medicines is seeking a highly motivated and driven Associate Director, Toxicology to lead nonclinical safety programs across a diverse pipeline built on Parabilis’ clinically validated Helicon™ pipeline. This is a hands-on scientific leadership role embedded in the discovery and early development organization, with accountability for advancing candidates from lead optimization through IND filing and beyond. The successful candidate will serve as the nonclinical safety lead on cross-functional project teams, working autonomously to define strategy, drive execution, influence candidate selection, and ensure robust safety assessment across our pipeline.

• Partner with discovery teams during Pre-LO/LO to identify safety liabilities, design early safety profiling studies, and guide candidate selection through science-based risk assessment.
• Serve as the primary toxicology lead on project teams, driving alignment across multiple Research and Clinical functions to ensure integrated and timely IND readiness. Develop and communicate candidate-specific toxicology risk assessments and go/no-go recommendations to project teams and leadership.
• Apply knowledge of injectable formulations (subcutaneous, intravenous, intramuscular) to anticipate and address local tolerance, excipient toxicity, and route-of-administration-specific safety considerations.
• Design and oversee the complete IND-enabling nonclinical safety package, including acute and repeat-dose toxicology, safety pharmacology, genotoxicity, and local tolerance studies, across relevant species.
• In collaboration with project team, select appropriate species, routes of administration, doses, and study durations based on scientific rationale and regulatory expectations
• Author and own nonclinical sections of INDs and CTAs and support regulatory interactions
• Maintain awareness of evolving FDA, EMA, and ICH guidance and proactively apply updates to program strategy.

• Select and manage CROs and specialty contract laboratories for GLP and non-GLP preclinical studies.
• Review study protocols, amendments, and final reports to ensure scientific rigor, GLP compliance, and alignment with regulatory expectations.
• Monitor study progress, interpret interim data, and make real-time scientific decisions to address unexpected findings or deviations.
• Oversee test article logistics, dose formulation preparation and stability, and chain-of-custody in coordination with CMC and Pharmaceutical Sciences.

• Operate with a high degree of scientific independence, defining strategy, prioritizing work, and resolving safety questions in close collaboration with project team.
• Communicate complex nonclinical safety data clearly and confidently to internal project teams, senior leadership, and external partners.
• Mentor junior scientists across the organization and contribute to scientific best practices
• Champion innovation in nonclinical safety tools and methodologies, including New Approach…