Sr. Scientist, Immune Repertoire Discovery

The Role

The Therapeutics Research group at Moderna is seeking a talented, experienced, and highly motivated Senior Scientist to implement scalable platforms for T cell repertoire analysis from patient and disease‑relevant samples. This individual will drive T cell profiling and antigen‑specific TCR discovery and functional validation efforts across oncology, autoimmunity, and other therapeutic areas where defining disease‑relevant T cell responses can inform translational biology, therapeutic design, and AI/ML model training.

The candidate will also help identify, characterize, and prioritize TCRs with potential utility for therapeutic development, including TCR‑T, TCR engager, and other TCR‑based modalities.

The Therapeutics Research group at Moderna is seeking a talented, experienced, and highly motivated Senior Scientist to implement scalable platforms for T cell repertoire analysis from patient and disease‑relevant samples. This individual will drive T cell profiling and antigen‑specific TCR discovery and functional validation efforts across oncology, autoimmunity, and other therapeutic areas where defining disease‑relevant T cell responses can inform translational biology, therapeutic design, and AI/ML model training.

The candidate will also help identify, characterize, and prioritize TCRs with potential utility for therapeutic development, including TCR‑T, TCR engager, and other TCR‑based modalities. The successful candidate will bring deep expertise in T cell immunology, antigen‑specific T cell repertoire analysis, TCR‑pMHC recognition, and functional screening. They will work closely with cross‑functional partners in bioinformatics, translational medicine, therapeutic immunology, protein engineering, and program teams to advance Moderna’s therapeutic and translational research programs.

This is a highly collaborative, hands‑on role for a scientist who is excited to build and refine discovery workflows, generate high‑quality biological datasets, and translate complex immune profiling results into actionable insights for therapeutic research.

• Establish and execute scalable workflows for TCR specificity mapping from patient samples, disease‑relevant samples, and internal or external datasets.
• Support antigen‑specific T cell discovery using approaches such as single‑cell profiling, TCR sequencing, functional screening, reporter assays, cell‑based assays, or NGS‑enabled readouts.
• Design and execute experiments to identify, validate, and prioritize disease‑relevant T cell responses and TCR candidates for downstream therapeutic evaluation.
• Contribute to translational oncology, autoimmunity, and other disease‑area work streams by applying TCR specificity‑mapping workflows to support immune monitoring, mechanism‑of‑action studies, and therapeutic hypothesis generation.
• Generate high‑quality, well‑annotated biological datasets that can support downstream computational analysis, AI/ML model development, therapeutic discovery, and translational interpretation.
• Partner with bioinformatics, computational biology, AI/ML, protein engineering, translational medicine, and program teams to connect immune profiling outputs with therapeutic design and candidate selection.
• Drive continued innovation of TCR discovery workflows by identifying, piloting, and integrating new experimental or computational approaches that improve scale, sensitivity, reproducibility, or biological resolution.
• Troubleshoot complex assay workflows, evaluate new deconvolution technologies, and recommend improvements to throughput, sensitivity, and data quality.

• PhD in immunology, molecular biology, cell biology, cancer biology, microbiology, bioengineering, or related discipline.
• At least 2 years of hands‑on post‑graduate experience in T cell biology, TCR‑pMHC recognition, antigen mapping, T cell repertoire analysis, immune profiling, or related T cell immunology platforms.
• Experience designing, executing, and troubleshooting complex immunology assays or T cell profiling workflows.
• Hands‑on experience with one or more relevant technologies, such as single‑cell…