Senior Scientist, Biomarker Discovery, Multiomics

Senior Scientist, Biomarker Discovery, Multiomics Skip to main content
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Not Applicable locations:
USA
- Massachusetts
- Cambridge (320 Bent Street) time type:
Full time posted on:
Posted Todaytime left to apply:
End Date:
August 13, 2026 (2 days left to apply) job requisition :
R411458
** Job Description
** We are seeking a highly skilled and experienced experimental and computational biologist with a strong background impacting Immunology Drug Discovery leveraging advanced multimodal and multi-omics technologies to join the Spatial and Single Cell Multiomics (SSM) Team within the Department of Data, AI & Genome Sciences (DAGS) at our company's Research Laboratories in Cambridge, MA. Our team leverages cutting-edge Spatial Multiomics (Cos Mx WTx, Xenium, COMET mIF, Digital Pathology, MSI) and multi-omics single cell approaches (REAP-seq/CITE-seq, CROP-seq/Perturb-Seq, Immune profiling, Multiome ATAC-seq) to drive Biomarker Discovery and innovation across the drug development pipeline, from pre-clinical to clinical stages.

SSM collaborates closely with therapeutic areas such as Oncology, Immunology, Neuroscience, and Cardiometabolic Disease, as well as functional areas including Data, AI & Genome Sciences, Data Science & Scientific Informatics, Quantitative Bioscience, and Chem Bio within the Discovery, Preclinical and Translational Medicine (DPTM) organization.
** Responsibilities:
*** Design and execute hands-on laboratory experiments for large-scale studies across single cell and spatial multiomics assays, including single cell RNA-seq, REAP-seq/CITE-seq, CROP-seq/Perturb-seq, immune profiling, Multiome ATAC-seq, and spatial multiomics platforms such as Cos Mx, Xenium, COMET mIF, and Digital Pathology.
* Support and develop perturbation, cell-culture, and tissue-based profiling studies to enable mechanistic studies and translationally relevant biological investigations.
* Collaborate closely with experimental biologists, automation engineers, computational scientists, data analysts, AIML data scientists, and therapeutic area subject matter experts to address biological questions, develop experimental strategies, and execute project plans.
* Independently drive projects from study design through execution, data interpretation, troubleshooting, and communication of results to stakeholders and senior leadership.
* Evaluate, implement, and scale emerging single cell and spatial technologies, computational approaches, and biological models for use in early discovery and translational research.
* Drive scientific impacts across technical work streams, helping to close multiple experimental and computational capability gaps on the team.
* Work in a matrixed environment aligned by therapeutic area, with primary support for Immunology and Oncology programs, and collaboration across other DAGS and DPTM efforts as needed.
* Clearly communicate to executive leadership including goals, assay procedures, experimental findings, and biological insights through presentations, written summaries, and cross-functional discussions.
** Education Minimum Requirement:
*** Ph.D. in molecular and cell biology or related disciplines with 0-3+ years of post-graduate experience, or Masters with 3-5+ years of post-graduate experience.
** Required Skills and…