Senior Research Associate (Stem Cell

Piper Companies is seeking a highly motivated Senior Research Associate II to support the development of innovative cell-based therapies. This role will contribute to stem cell research, genetic engineering studies, and translational biology programs through hands-on laboratory experimentation and data analysis. This role is out of Cambridge, MA.

• Perform routine culture, expansion, maintenance, and differentiation of human stem cells and other mammalian cell lines.
• Support research initiatives involving cellular engineering, gene modification, and evaluation of cellular function in both laboratory and preclinical settings.
• Monitor cell health, growth characteristics, sterility, and experimental quality while maintaining detailed laboratory records.
• Carry out molecular and cellular biology techniques, including nucleic acid extraction, cDNA preparation, gene expression analysis, and protein-based assays.
• Conduct experiments using technologies such as flow cytometry, quantitative PCR, digital PCR, ELISA, immunofluorescence, and related analytical methods.
• Assist in developing, optimizing, and troubleshooting experimental workflows and standard operating procedures.
• Compile, interpret, and present experimental findings using appropriate statistical and analytical methods.
• Maintain laboratory inventory, prepare reagents, monitor supplies, and coordinate purchasing of laboratory materials and equipment.

• 3+ years of hands-on experience with human pluripotent stem cell culture (IPSC), differentiation, and maintenance
• Experience in regenerative medicine, cell therapy, gene editing, or related therapeutic development fields.
• Must have experience working in a GMP-regulated biotech/biopharmaceutical environment
• Extensive experience performing techniques such as flow cytometry, RT-qPCR, ddPCR, ELISA, and immunostaining methods.
• Bachelor's or Master's degree in Biology, Cell Biology, Molecular Biology, Biotechnology, Regenerative Medicine, Genetics, or a related scientific discipline
• Schedule requires weekend work – 40 hours per week (Thurs-Monday Shift or Fri-Tues)

• Salary: $70,000 - $100,000, commensurate with experience
• Comprehensive Benefits:
  Medical, Dental, Vision 401k, Paid Holidays, PTO (Paid Time Off), Sick leave required as by law

This job opens for applications on 8/12/2026. Applications for this job will be accepted for at least 30 days from the posting date.

Research Associate, Scientist, Senior Research Associate, RA, IPSC, Human Pluripotent, Stem Cell, Cell Culture, Cell Therapy, Regenerative Medicine, Gene Editing, GMP, Good Manufacturing Practice, Pharma, Biotech, Immunostaining, RT-qPCR, qPCR, ddPCR, ELISA, Western Blot, Immunology, Molecular Biology, DNA, RNA, Cell Biology, Associate Scientist, Cellular Engineering, Flow Cytometry, Immunohistochemistry, 3D, 2D, Immunofluorescence, Staining, Aseptic Technique, Process Development, Genetic Engineering, Differentiation, Tissue Culture, Human Stem, Induced Pluripotent Stem Cell, CHO, Pluripotent, Emrbyonic, Immune Cell, Heart cell, Pancreatic Cell, Kidney Cell, Liver Cell, Disease Modeling

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