Sr. Scientist, Delivery Sciences

The Role

We are seeking an accomplished Scientist to lead the development of targeted lipid nanoparticle (LNP) formulations within our fast-paced, cross-functional R&D organization. In this role, you will advance the science of LNP self-assembly, engineer delivery systems for small- and large-molecule payloads beyond the liver and leverage state-of-the-art analytical techniques to establish structure–function relationships that drive biological performance. You will also integrate high-throughput formulation, laboratory automation, and AI/ML-enabled approaches to accelerate LNP discovery and support data-driven decision-making across multidisciplinary research programs.

We are seeking an accomplished Scientist to lead the development of targeted lipid nanoparticle (LNP) formulations within our fast-paced, cross-functional R&D organization. In this role, you will advance the science of LNP self-assembly, engineer delivery systems for small- and large-molecule payloads beyond the liver and leverage state-of-the-art analytical techniques to establish structure–function relationships that drive biological performance. You will also integrate high-throughput formulation, laboratory automation, and AI/ML-enabled approaches to accelerate LNP discovery and support data-driven decision-making across multidisciplinary research programs.

• Drive research programs on targeted, extra-hepatic LNP delivery—from hypothesis generation through in-vitro / in-vivo evaluation
• Develop and optimize LNP self-assembly processes; refine composition, payload loading, and surface modifications for tissue and cell-type specificity
• Advance LNP formulation discovery by leveraging high-throughput formulation, automation, and AI/ML-enabled data analysis to accelerate innovation, optimize formulations, and drive data-informed decision-making across multidisciplinary teams
• Independently Design and execute experiments; analyze, interpret, and clearly communicate data to multidisciplinary project teams and leadership
• Implement and innovate advanced physicochemical and biophysical characterization methods (e.g., DLS, CryoEM, SAXS, ITC, NMR, nFCM etc) to elucidate structure–function relationships
• Maintain rigorous electronic laboratory notebooks, SOPs, and study documentation consistent with company expectations
• Provide scientific leadership and mentorship to research associates while partnering with cross-functional teams and external collaborators to prioritize activities, solve technical challenges, and ensure the timely achievement of project objectives and key milestones.

• Ph.D. in Pharmaceutical Sciences, Chemistry, Chemical Engineering, Materials Science, or a related discipline with 2+ years of experience.
• Deep expertise in lipid nanoparticle (LNP) design, formulation, and physicochemical characterization, with experience advancing targeted or extra-hepatic delivery platforms preferred.
• Demonstrated experience implementing high-throughput formulation workflows, laboratory automation, and computational or AI/ML-enabled data analysis to accelerate discovery and support data-driven decision-making.
• Proven leadership experience mentoring scientists and research associates, with a track record of driving cross-functional collaboration and delivering research objectives in a fast-paced environment.
• Proficiency with a broad suite of analytical techniques for nanoparticle size, morphology, composition, and stability assessment
• This position is site-based, requiring you to be at Moderna’s site full-time. This position is not eligible for remote work

• Demonstrated ability to plan and manage multiple projects in a highly collaborative, fast-paced setting
• Clear, concise scientific communication—written and verbal—with a track record of peer-reviewed publications and/or patents
• Commitment to inclusive teamwork, continuous learning, and high scientific rigor

At Moderna, we believe that when you feel your best, you can do your best work. That’s why our benefits and well‑being resources are designed to…