Senior Data Scientist, Computational Chemistry at Parabilis Medicines Cambridge, MA

Senior Data Scientist, Computational Chemistry job at Parabilis Medicines. Cambridge, MA.

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides - Helicons - capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company's lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the beta-catenin:

TCF interaction, a central node in the Wnt/beta-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/beta-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.

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We are seeking a highly talented and self-motivated person to contribute to the development of the Computational Drug Discovery group, a strategic function in Data Science that is part of Parabilis's platform discovery engine for Helicon stapled-peptide drugs. The skill sets of the group includes state-of-the-art machine learning/generative AI, molecular modeling, cheminformatics and data science towards the discovery and development of Helicon stapled-peptide drugs.

You'll be part of a data science team that is a central pillar of Parabilis's innovative discovery platform and pipelines targeting “undruggable” genes of major therapeutic interest to patients. Our data science team is an integrated team, ranging from computational biology, bioinformatics, computational drug discovery, research informatics and engineering. We work at the interface of chemistry, biology, clinical and computational sciences, and are responsible for all aspects of data science, from building the discovery pipeline to supporting and developing our discovery.

• Provide computational expertise towards, but not limited to, ternary complex designs for degraders and other proximity-based modalities, hit-to-lead progression using multi-objective optimization, initiating new projects, new drug-target assessments and advancing drug-pipeline projects towards the clinic.
• Identify, implement, and apply 3D modeling techniques for sampling Helicon peptide conformations in presence of a target, in ternary complex, and in different physiological environments.
• Analyze and derive 3D peptide-structure relationships.
• Exemplify scientific leadership by partnering across functions and working within a team of talented and passionate scientists to discover drugs.
• Interface with internal and external partners.

• PhD in Computational Chemistry, Protein Engineering, Chemistry, Physics, Macromolecular sciences or close-related field
• 5+ years of pharma/biotech industry experience in computational rational drug .
• Demonstrated experience with ternary complex design and understanding, peptide design or protein engineering and a good understanding of peptide structure-property relationships (e.g. helicity and amphiphilicity metrics, cell penetration).
• Demonstrated mastery of modern computational chemistry including, but not limited to, peptide folding and docking, use of co-folding foundation models, such as Boltz, structure-based design (receptor and ligand-based), scaffold hopping, docking and conformational analysis.
• An understanding of modern drug discovery including, but not limited to, medicinal chemistry, multi-parametric optimization, molecular recognition principles, and the ability to adapt and translate these principles to stapled peptides.
• Excellent communication and collaboration skills, with the ability to work well in a multidisciplinary environment
• Excellent organizational skills and attention to…