Associate Scientist: Downstream Process Development

Associate Scientist
- Contract
- Cambridge, MA

Passionate about analytical chemistry and process development? Join a team advancing cutting-edge oligonucleotide manufacturing technologies.

Proclinical is seeking an Associate Scientist II will join the CMC - DS Process Development Group at our client's facility in the US.

The successful candidate will be supporting process development efforts to incorporate novel chemistries into the manufacturing platform.

• Required:
  
  BS in Chemistry or Chemical Engineering
• Process development experience/background
• Strong analytical chemistry background and hands-on laboratory experience
• Chemistry background with experience running analytical testing, particularly LC/HPLC
• Understanding of analytical techniques such as pH, Osmolality, Conductivity, HPLC, and LC-MS
• Strong laboratory documentation and record-keeping practices
• Knowledge of oligonucleotide manufacturing, including:
  Phosphoramidite chemistry, Chromatography, and Ultrafiltration
• Experience with relevant analytical testing software, e.g., Agilent and UNICORN laboratory software

• Support oligonucleotide synthesis method development, optimization, and scale-up
• Support downstream processing method development
• Execute in-process analytical testing
• Partner with research and process scientists to develop robust processes for novel chemistries
• Maintain strong laboratory documentation and record-keeping
• Maintain a safe, clean, and orderly laboratory environment
• Assist with routine laboratory and equipment maintenance

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