Research Associate III - Traverso Lab

About the Traverso Lab

The Traverso Laboratory focuses on translational medicine at the intersection of engineering, biology, and clinical care. Our goal is to develop technologies that improve human health, including advanced drug-delivery systems, diagnostics, biomaterials, medical devices, and therapeutic platforms.

The laboratory is led by Dr. Giovanni Traverso and includes a multidisciplinary team of engineers, scientists, clinicians, research staff, postdoctoral fellows, and students working across the Broad Institute, MIT, Brigham and Women’s Hospital, and Harvard Medical School.

The Research Associate III – Bioanalytics will support the development, implementation, and operation of bioanalytical workflows for the Traverso Laboratory, with the position primarily based at the Broad Institute in Cambridge, Massachusetts.

The individual will serve as a central technical resource for the measurement and characterization of drugs, metabolites, biomarkers, formulation components, and other analytes across a range of translational research programs. A significant portion of the role is expected to involve high-performance liquid chromatography and liquid chromatography–mass spectrometry, including the development, qualification, execution, and troubleshooting of analytical methods.

The position may also support additional analytical techniques, including enzyme-linked immunosorbent assays and other quantitative biochemical or physicochemical assays, depending on project requirements. The balance of responsibilities will evolve as new analytical workflows are established and the needs of the laboratory’s research portfolio change.

In addition to technical bioanalytical responsibilities, the Research Associate III will contribute to laboratory operations, training, safety, procurement, equipment stewardship, and workflow organization. The individual will work closely with Aaron and other Broad-based team members while collaborating with researchers across the broader Traverso Laboratory.

There may also be limited near‑term support for establishing the laboratory’s new Brigham and Women’s Hospital research space, particularly with respect to equipment, supplies, safety systems, and laboratory workflows to synergize with the collaborative projects between the Broad and BWH. The position itself, however, will remain Broad‑centric.

• Develop, optimize, qualify, and execute analytical methods for the quantitative measurement of drugs, metabolites, biomarkers, excipients, and other analytes.
• Operate and support high-performance liquid chromatography systems for assay development, purity assessment, stability studies, release testing, and related analytical applications.
• Operate and support liquid chromatography–mass spectrometry workflows for sensitive and selective quantification of analytes in biological and nonbiological matrices.
• Assist with sample preparation, extraction, dilution, filtration, and processing methods for plasma, serum, tissue, formulations, release media, and other sample types.
• Develop and conduct ELISAs and other plate‑based assays when required by project needs.
• Evaluate analytical performance, including sensitivity, specificity, linearity, accuracy, precision, recovery, matrix effects, stability, carryover, and reproducibility.
• Identify and troubleshoot technical issues involving instrumentation, chromatography, sample preparation, assay performance, and data quality.
• Support analytical method transfer, standardization, and implementation across research projects and collaborating groups.
• Maintain familiarity with emerging analytical technologies and recommend new instrumentation, methods, or workflows when appropriate.

• Operate, maintain, calibrate, and coordinate servicing of HPLC, LC-MS, plate-reader, and related analytical equipment.
• Establish preventive‑maintenance schedules and maintain accurate instrument usage, calibration, and service records.
• Develop standardized procedures for instrument operation, data acquisition, data processing, and quality review.
• Analyze experimental data using…