Scientist II​/Senior Scientist, Peptide Discovery Scientist

ODDITY is a consumer tech company that builds and scales digital-first brands to disrupt the offline-dominated beauty and wellness industries. The company serves over 40 million users with its AI-driven online platform, deploying data science to identify consumer needs, and developing solutions in the form of beauty and wellness products. ODDITY owns IL MAKIAGE, Spoiled Child, and medical-grade skincare and telehealth platform METHODIQ.

ODDITY LABS is our cutting-edge biotechnology R&D center, powering science-backed product innovation through the discovery and development of new molecules, probiotics, peptides, and other biological modalities. Unlike pharmaceuticals, ingredient innovation in the beauty and wellness industry has remained stagnant for decades. We are deploying patented, proprietary technologies and capabilities, including AI-based molecule discovery and advanced phenotypic databases, to understand the biological mechanisms that drive cellular behavior and develop uniquely efficacious products for beauty and wellness applications.

Innovations from the ODDITY LABS will power game-changing products through ODDITY’s current brands, as well as future brands. ODDITY operates with business headquarters in New York City, an R&D center in Tel Aviv, Israel, and a biotechnology lab in Boston. Our culture is fast-paced, innovative, agile, and offers every team member the opportunity to drive a big impact.

We are seeking a Peptide Discovery Scientist (Scientist II / Senior Scientist) (title to be determined based on experience) to own peptide discovery programs and build decision-grade assay platforms across dermatology discovery. As the scientific driver for one or more parallel work streams, you will lead efforts from initial library selection through lead optimization while mentoring junior scientists and partnering cross-functionally with chemistry, formulation, and external CROs.

In this role you will:

• Lead peptide hit discovery and SAR campaigns to identify and optimize peptide leads against novel therapeutic targets.
• Apply deep knowledge of macrocyclic and linear peptide properties required for different routes of administration to guide design and library strategy.
• Design, execute, and interpret data from either computational design platforms or library-based peptide screening technologies, including OBOC, mRNA display, phage display, AS/MS.
• Manage external CRO projects end-to-end across study design, quality control, timeline accountability, and data analysis to inform go/no-go decisions and guide iterative peptide design.
• Build, run, and interpret complex assay cascades spanning biophysical characterization, functional protein-/cell-based assays, and safety screening to guide candidate progression.
• Collaborate with formulation chemists on peptide bioavailability, stability, and delivery strategy.
• Serve as the technical owner for program milestones, including experimental design, data interpretation, strategic recommendations, and documentation for internal review.
• Foster a culture of scientific rigor, innovation, and leadership within ODDITY LABS and across ODDITY teams.

• Ph.D. in Protein Engineering, Chemistry, Biochemistry, Chemical Biology, or a related field with a focus on peptide chemistry, accompanied by 3+ years of industry experience.
• Demonstrated experience in peptide hit discovery and SAR campaigns, using structure-based and ligand-based drug design to guide rational peptide modifications.
• Proven experience building, executing, and interpreting complex assay cascades, spanning biophysical characterization, functional protein screening, and cell-based models.
• Deep knowledge of macrocyclic and linear peptide properties required for different routes of administration, paired with hands-on experience in library-based screening technologies (e.g., OBOC, mRNA display, phage display, AS/MS etc).
• Working knowledge of protein biophysics (stability, folding, aggregation) and standard characterization methods (CD, DSF, SEC-MALS).
• Experience managing external CRO engagements and collaborating cross-functionally with internal chemistry, formulation, and safety science teams.
• Strong problem-solving skills driven by deep scientific curiosity to tackle complex anti-aging research questions.

• Familiarity with machine learning and AI-driven platforms for sequence optimization, property prediction, and novel scaffold generation
• Experience with computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar) for molecular modeling, conformational sampling, and molecular dynamics simulations
• Direct experience in dermatology R&D — anti-aging mechanisms, pigmentation, acne/sebaceous biology, or inflammatory skin conditions

• Competitive compensation and benefits package.
• This position is in-office in our Cambridge, Massachusetts office and laboratory.
• The salary for this position is negotiable and commensurate with experience.