Senior Scientist, Immunology

This is a full-time, lab-based role based in Cambridge, MA. Only applicants currently living within commuting distance of Cambridge, MA will be considered.

Marengo Therapeutics is developing first-in-class bi-specific T cell activators that stimulate and expand anti-tumor T cells to generate deep, durable anti-tumor immunity. Our lead program is in Phase 2 clinical trials, currently being evaluated across multiple solid tumor indications, backed by an advanced antibody discovery platform and a growing pipeline of multi-specific immune-modulating therapeutics.

Building on that clinical foundation, our TriSTAR platform is enabling the development of a new generation of precision T cell engagers (TCEs). TriSTAR molecules are multi-specific antibody fusions that pair our proprietary antibodies against germline-encoded V  regions of the TCR with a T cell co-stimulatory moiety and a tumor-associated antigen binder — selectively activating and expanding memory V  T cell subsets while redirecting them to the tumor in a single molecule.

This differentiated, built-in-costimulation mechanism is designed to overcome the poor T cell quality and exhaustion that limit conventional CD3-based T cell engagers, particularly in immunologically "cold" tumors.

We're looking for a Senior Scientist with deep in vitro immunology expertise to help drive our next generation of T cell engagers and immune-modulating biologics. You will design and lead cell-based assays using primary human, NHP and rodent immune cells — generating mechanistic data that shapes program strategy — while serving as a subject matter expert on program teams.

• PhD in Immunology, Cell Biology, or a related discipline with 4+ years of relevant experience, or MS with 8+ years of hands-on immunology experience.
• Demonstrated experience executing immunological assays with primary immune cells.
• Hands-on experience with T cell functional assays, including activation, proliferation, cytokine production, and cytotoxicity readouts.
• Strong data analysis and interpretation skills, with the ability to translate complex datasets into clear conclusions.
• Expertise with multi-parameter flow cytometry.
• Excellent organizational and communication skills, with the ability to drive cross-functional collaboration in a matrix environment.
• Working knowledge of Microsoft Office and standard scientific software.

• Direct experience supporting T cell engagers, bispecific or multi-specific antibodies, or other TCR-directed biologics, including TDCC and cytokine release assessment.
• Familiarity with TCR biology, V  repertoire analysis, or T cell memory and exhaustion differentiation.
• Expertise in immune cell isolation (including magnetic separation methods).
• Experience developing and validating primary and immortalized cell-based assays.
• Experience designing and implementing 3D culture models (e.g., organoids and/or spheroids), including tumor killing readouts.
• Experience with real-time cell analysis and imaging technologies such as Incu Cyte.
• Experience with analytical tools such as Flow Jo, OMIQ, and Graph Pad Prism.
• Prior experience in biopharmaceutical R&D or drug development.
• Track record of scientific productivity and innovation as demonstrated through project outcomes and/or publications.

• Membership within a growing, CARING, and collegial organization
• Highly intellectual and analytical team, that challenges the status quo and loves innovation
• Being part of a passionate, involved, and cutting-edge Research Team
• Exposure to pioneering science and the discovery of drugs to help treat patients with cancer

• Independently design, optimize, and execute in vitro and ex vivo cellular assays leveraging…