Senior Research Lab Tech, Mass Spectrometry

• Run and maintain the laboratory's mass spectrometry platform

• Execute workflows spanning human tissue processing, immunofluorescence imaging, laser microdissection, low-input proteomic sample preparation, and ultra-sensitive mass spectrometry

• Generate high-quality proteomic data on the Orbitrap Astral

• Work closely with postdoctoral and computational colleagues

• Help establish core methods and operational standards

• Develop or contribute to modifications of assay techniques, experimental protocols, and new procedures

• Synthesize and interpret results

• Prepare written and/or verbal status reports

• Perform statistical analysis and make recommendations

• Independently perform non-routine, highly specialized experimental procedures

• Compose and potentially present sections of research reports and manuscripts

Requirements

• Bachelor's Degree in a related field required (Biochemistry, Analytical Chemistry, Molecular Biology, or a related field)
• 3–5 years of experience in an academic or laboratory research setting required
• Minimum of 3 years of hands-on LC-MS experience required
• Hands-on operation, routine maintenance, and systematic troubleshooting of complex LC-MS setups for high-throughput quantitative proteomics
• Prior experience with nanoflow workflows and the Orbitrap Astral, Vanquish Neo, and Evosep One highly desirable
• Expertise in protein extraction and enzymatic digestion
• Experience with low-input workflows and PTM enrichments such as phosphoproteomics ideally
• Experience optimizing and troubleshooting protocols and MS acquisition methods
• Experience documenting rigorous laboratory SOPs
• Practical experience with human tissue sectioning, including cryosectioning and FFPE, immunofluorescence staining, or laser microdissection is a strong advantage
• Excellent communication skills
• Good interpersonal skills and ability to oversee the work of others
• Ability to work independently
• Ability to identify problems and develop solutions
• Ability to prioritize tasks and set deadlines
• Strong database management and overall computer skills
• Ability to function with speed, precision, and understanding of the theory behind tests and procedures

Core Competencies

Demonstrates expertise in mass spectrometry, particularly with LC-MS and the Orbitrap Astral, while effectively synthesizing and interpreting proteomic data. Capable of developing and optimizing experimental protocols and maintaining rigorous laboratory standards.

Highest-signal resume keywords

• LC-MS Experience
• Orbitrap Astral Operation
• Protein Extraction Expertise
• Statistical Analysis Skills
• Laboratory SOP Documentation

ATS Optimization Keywords

Hard Skills

• Mass Spectrometry
• Proteomic Sample Preparation
• Human Tissue Processing
• Immunofluorescence Imaging
• Laser Microdissection
• Statistical Analysis
• Assay Technique Development
• Experimental Protocol Modification
• Low-Input Workflows
• PTM Enrichment

Soft Skills

• Excellent Communication Skills
• Interpersonal Skills
• Problem-Solving Ability
• Independence
• Task Prioritization

Industry Keywords

• Biochemistry
• Analytical Chemistry
• Molecular Biology
• Laboratory Research
• High-Throughput Quantitative Proteomics

Tools & Technologies

• Orbitrap Astral
• Vanquish Neo
• Evosep One
• Database Management Software