Vivo Study Specialist

About Parabilis Medicines

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides - Helicons™ - capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the beta-catenin:

TCF interaction, a central node in the Wnt/beta-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/beta-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.

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We are seeking a highly motivated In Vivo Study Specialist to join our In Vivo Pharmacology team and contribute to the preclinical evaluation of Helicon™ peptide therapeutics for oncology. This is a hands-on laboratory role built around two core skill sets: executing in vivo pharmacology studies in mouse oncology models, and preparing high-quality ex vivo assays from tumor and normal tissue for downstream molecular and immune analysis.

You will generate the preclinical data that advances novel therapeutic candidates toward clinical development.

The successful candidate will be an integral member of a collaborative, multidisciplinary research team and will work closely with Discovery Biology, Translational Sciences, DMPK, and external CRO partners. This role offers the opportunity to expand scientific expertise in oncology drug discovery while developing as a drug hunter through exposure to study design, data interpretation, translational pharmacology, and cross-functional research strategy.

Reporting to the Associate Director of Vivarium and In Vivo Operations, the ideal candidate will bring deep, hands-on in vivo technical skill, strong command of ex vivo tissue processing and assay preparation, and a passion for advancing innovative therapeutics.

• Independently execute in vivo pharmacology studies supporting target validation, lead optimization, mechanism-of-action, and efficacy evaluation of Helicon therapeutics.
• Perform mouse oncology studies using xenograft, syngeneic, patient-derived xenograft (PDX), and genetically engineered mouse models (GEMMs).
• Conduct routine and advanced in vivo procedures with a high standard of technical precision, including:
  • Intravenous (IV), intraperitoneal (IP), subcutaneous (SC), and oral gavage (PO) dosing
  • Tumor cell implantation, caliper-based tumor measurement, and tumor growth monitoring
  • Serial blood collection and pharmacokinetic (PK) sampling via multiple routes
  • Body weight monitoring and clinical observations per IACUC-approved protocols
  • Terminal necropsy and systematic collection of tumor and tissue specimens for downstream analysis
  • Minor and major survival surgeries, including oncology-specific surgical procedures
• Execute PK/PD and efficacy studies evaluating tumor growth inhibition, pharmacodynamic biomarkers, drug exposure, and mechanism of action.

• Own the ex vivo workflow from tissue harvest through assay-ready sample: dissection, fixation, freezing, and preservation of tumor and normal tissues for molecular and cellular analysis.
• Prepare tissue for histology and IHC shipment
• Extract RNA/DNA/Protein and process plasma or tissue lysates for downstream Western Blot, qPCR, ELISA, or multiplex cytokine/biomarker profiling.

• Evaluate and implement emerging in vivo models and ex vivo assay technologies to support target validation and translational research.
• Maintain detailed experimental documentation and contribute to study reports, presentations, and regulatory…